ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI

Ferritin-conjugated antibody has been used to identify by electron microscopy the sites at which nephrotoxic globulins localize in rat kidney during acute experimental glomerulonephritis. Antibody was concentrated in the glomerular basement membrane and in basement membrane-like material contained i...

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Autores principales: Andres, Giuseppe A., Morgan, Councilman, Hsu, Konrad C., Rifkind, Richard A., Seegal, Beatrice C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137532/
https://www.ncbi.nlm.nih.gov/pubmed/13861458
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author Andres, Giuseppe A.
Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Seegal, Beatrice C.
author_facet Andres, Giuseppe A.
Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Seegal, Beatrice C.
author_sort Andres, Giuseppe A.
collection PubMed
description Ferritin-conjugated antibody has been used to identify by electron microscopy the sites at which nephrotoxic globulins localize in rat kidney during acute experimental glomerulonephritis. Antibody was concentrated in the glomerular basement membrane and in basement membrane-like material contained in distended cisternae of the endoplasmic reticulum. These data confirm and amplify, at the ultrastructural level, the results of studies obtained with the fluorescent antibody technique, and are consistent with the hypothesis that the cisternae and capillary basement membrane possess common proteins.
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spelling pubmed-21375322008-04-17 ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI Andres, Giuseppe A. Morgan, Councilman Hsu, Konrad C. Rifkind, Richard A. Seegal, Beatrice C. J Exp Med Article Ferritin-conjugated antibody has been used to identify by electron microscopy the sites at which nephrotoxic globulins localize in rat kidney during acute experimental glomerulonephritis. Antibody was concentrated in the glomerular basement membrane and in basement membrane-like material contained in distended cisternae of the endoplasmic reticulum. These data confirm and amplify, at the ultrastructural level, the results of studies obtained with the fluorescent antibody technique, and are consistent with the hypothesis that the cisternae and capillary basement membrane possess common proteins. The Rockefeller University Press 1962-05-01 /pmc/articles/PMC2137532/ /pubmed/13861458 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Andres, Giuseppe A.
Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Seegal, Beatrice C.
ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title_full ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title_fullStr ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title_full_unstemmed ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title_short ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY : THE BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI
title_sort electron microscopic studies of experimental nephritis with ferritin-conjugated antibody : the basement membranes and cisternae of visceral eithelial cells in nephritic rat glomeruli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137532/
https://www.ncbi.nlm.nih.gov/pubmed/13861458
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