RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION

Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockad...

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Detalles Bibliográficos
Autor principal: Lee, Leung
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137542/
https://www.ncbi.nlm.nih.gov/pubmed/14463528
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author Lee, Leung
author_facet Lee, Leung
author_sort Lee, Leung
collection PubMed
description Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions of thrombin. In the rabbit the reticuloendothelial system may constitute the major protective mechanism against the vasculo-occlusive lesions of the generalized Shwartzman reaction, which appears to be the direct consequence of intravascular fibrin formation and deposition.
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spelling pubmed-21375422008-04-17 RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION Lee, Leung J Exp Med Article Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions of thrombin. In the rabbit the reticuloendothelial system may constitute the major protective mechanism against the vasculo-occlusive lesions of the generalized Shwartzman reaction, which appears to be the direct consequence of intravascular fibrin formation and deposition. The Rockefeller University Press 1962-05-01 /pmc/articles/PMC2137542/ /pubmed/14463528 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lee, Leung
RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title_full RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title_fullStr RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title_full_unstemmed RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title_short RETICULOENDOTHELIAL CLEARANCE OF CIRCULATING FIBRIN IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION
title_sort reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized shwartzman reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137542/
https://www.ncbi.nlm.nih.gov/pubmed/14463528
work_keys_str_mv AT leeleung reticuloendothelialclearanceofcirculatingfibrininthepathogenesisofthegeneralizedshwartzmanreaction

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