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LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Si...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1962
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137544/ https://www.ncbi.nlm.nih.gov/pubmed/14496913 |
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author | Sanford, Jay P. Hunter, Betty W. Donaldson, Paul |
author_facet | Sanford, Jay P. Hunter, Betty W. Donaldson, Paul |
author_sort | Sanford, Jay P. |
collection | PubMed |
description | 1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication and subsequently evoked a leucocytic response. Bacterial multiplication did not occur in glomeruli or renal tubular cells. Bacteria did not appear within renal tubular lumina until microabscesses were well developed in the renal interstitium. Bacteriuria appeared late and represented secondary invasion rather than filtration of organisms. The infection healed spontaneously but, while sterile, the parenchymal scars contained large amounts of residual bacterial antigen. The persistence of bacterial antigen did not result in continuing inflammatory changes or progressive scarring. 3. The persistence of bacterial antigens is postulated to constitute a major antigenic stimulus responsible for active immunity in experimental hematogenous pyelonephritis. |
format | Text |
id | pubmed-2137544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1962 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21375442008-04-17 LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS Sanford, Jay P. Hunter, Betty W. Donaldson, Paul J Exp Med Article 1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication and subsequently evoked a leucocytic response. Bacterial multiplication did not occur in glomeruli or renal tubular cells. Bacteria did not appear within renal tubular lumina until microabscesses were well developed in the renal interstitium. Bacteriuria appeared late and represented secondary invasion rather than filtration of organisms. The infection healed spontaneously but, while sterile, the parenchymal scars contained large amounts of residual bacterial antigen. The persistence of bacterial antigen did not result in continuing inflammatory changes or progressive scarring. 3. The persistence of bacterial antigens is postulated to constitute a major antigenic stimulus responsible for active immunity in experimental hematogenous pyelonephritis. The Rockefeller University Press 1962-09-01 /pmc/articles/PMC2137544/ /pubmed/14496913 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Sanford, Jay P. Hunter, Betty W. Donaldson, Paul LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title | LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title_full | LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title_fullStr | LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title_full_unstemmed | LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title_short | LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS |
title_sort | localization and fate of escherichia coli in hematogenous pyelonephritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137544/ https://www.ncbi.nlm.nih.gov/pubmed/14496913 |
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