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LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS

1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Si...

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Detalles Bibliográficos
Autores principales: Sanford, Jay P., Hunter, Betty W., Donaldson, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137544/
https://www.ncbi.nlm.nih.gov/pubmed/14496913
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author Sanford, Jay P.
Hunter, Betty W.
Donaldson, Paul
author_facet Sanford, Jay P.
Hunter, Betty W.
Donaldson, Paul
author_sort Sanford, Jay P.
collection PubMed
description 1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication and subsequently evoked a leucocytic response. Bacterial multiplication did not occur in glomeruli or renal tubular cells. Bacteria did not appear within renal tubular lumina until microabscesses were well developed in the renal interstitium. Bacteriuria appeared late and represented secondary invasion rather than filtration of organisms. The infection healed spontaneously but, while sterile, the parenchymal scars contained large amounts of residual bacterial antigen. The persistence of bacterial antigen did not result in continuing inflammatory changes or progressive scarring. 3. The persistence of bacterial antigens is postulated to constitute a major antigenic stimulus responsible for active immunity in experimental hematogenous pyelonephritis.
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spelling pubmed-21375442008-04-17 LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS Sanford, Jay P. Hunter, Betty W. Donaldson, Paul J Exp Med Article 1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication and subsequently evoked a leucocytic response. Bacterial multiplication did not occur in glomeruli or renal tubular cells. Bacteria did not appear within renal tubular lumina until microabscesses were well developed in the renal interstitium. Bacteriuria appeared late and represented secondary invasion rather than filtration of organisms. The infection healed spontaneously but, while sterile, the parenchymal scars contained large amounts of residual bacterial antigen. The persistence of bacterial antigen did not result in continuing inflammatory changes or progressive scarring. 3. The persistence of bacterial antigens is postulated to constitute a major antigenic stimulus responsible for active immunity in experimental hematogenous pyelonephritis. The Rockefeller University Press 1962-09-01 /pmc/articles/PMC2137544/ /pubmed/14496913 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sanford, Jay P.
Hunter, Betty W.
Donaldson, Paul
LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title_full LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title_fullStr LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title_full_unstemmed LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title_short LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS
title_sort localization and fate of escherichia coli in hematogenous pyelonephritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137544/
https://www.ncbi.nlm.nih.gov/pubmed/14496913
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