URINARY CALCULI IN GERMFREE RATS

In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared whe...

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Detalles Bibliográficos
Autores principales: Gustafsson, Bengt E., Norman, Arne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137552/
https://www.ncbi.nlm.nih.gov/pubmed/13903130
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author Gustafsson, Bengt E.
Norman, Arne
author_facet Gustafsson, Bengt E.
Norman, Arne
author_sort Gustafsson, Bengt E.
collection PubMed
description In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared when germfree animals were contaminated with the intestinal flora from conventional rats. The calculus formation can readily be explained by the high calcium, high citrate, and high pH of the urine. This pattern was changed to that of conventional rats when the germfree rats were infected with intestinal microorganisms.
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spelling pubmed-21375522008-04-17 URINARY CALCULI IN GERMFREE RATS Gustafsson, Bengt E. Norman, Arne J Exp Med Article In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared when germfree animals were contaminated with the intestinal flora from conventional rats. The calculus formation can readily be explained by the high calcium, high citrate, and high pH of the urine. This pattern was changed to that of conventional rats when the germfree rats were infected with intestinal microorganisms. The Rockefeller University Press 1962-09-01 /pmc/articles/PMC2137552/ /pubmed/13903130 Text en Copyright © Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gustafsson, Bengt E.
Norman, Arne
URINARY CALCULI IN GERMFREE RATS
title URINARY CALCULI IN GERMFREE RATS
title_full URINARY CALCULI IN GERMFREE RATS
title_fullStr URINARY CALCULI IN GERMFREE RATS
title_full_unstemmed URINARY CALCULI IN GERMFREE RATS
title_short URINARY CALCULI IN GERMFREE RATS
title_sort urinary calculi in germfree rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137552/
https://www.ncbi.nlm.nih.gov/pubmed/13903130
work_keys_str_mv AT gustafssonbengte urinarycalculiingermfreerats
AT normanarne urinarycalculiingermfreerats

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