EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO

Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of plate...

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Detalles Bibliográficos
Autores principales: Horowitz, Herbert I., Des Prez, Roger M., Hook, Edward W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137562/
https://www.ncbi.nlm.nih.gov/pubmed/13954979
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author Horowitz, Herbert I.
Des Prez, Roger M.
Hook, Edward W.
author_facet Horowitz, Herbert I.
Des Prez, Roger M.
Hook, Edward W.
author_sort Horowitz, Herbert I.
collection PubMed
description Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet factor 3. Since platelet factor 3 can be demonstrated in platelet-poor plasma as well as platelet-rich plasma after endotoxin injection, it seems likely that an actual transfer of factor 3 from platelets to plasma occurs and that this activity is then rapidly inactivated or cleared from the blood stream.
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spelling pubmed-21375622008-04-17 EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO Horowitz, Herbert I. Des Prez, Roger M. Hook, Edward W. J Exp Med Article Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet factor 3. Since platelet factor 3 can be demonstrated in platelet-poor plasma as well as platelet-rich plasma after endotoxin injection, it seems likely that an actual transfer of factor 3 from platelets to plasma occurs and that this activity is then rapidly inactivated or cleared from the blood stream. The Rockefeller University Press 1962-10-31 /pmc/articles/PMC2137562/ /pubmed/13954979 Text en ©Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Horowitz, Herbert I.
Des Prez, Roger M.
Hook, Edward W.
EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title_full EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title_fullStr EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title_full_unstemmed EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title_short EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : II. ENHANCEMENT OF PLATELET FACTOR 3 ACTIVITY IN VITRO AND IN VIVO
title_sort effects of bacterial endotoxin on rabbit platelets : ii. enhancement of platelet factor 3 activity in vitro and in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137562/
https://www.ncbi.nlm.nih.gov/pubmed/13954979
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AT hookedwardw effectsofbacterialendotoxinonrabbitplateletsiienhancementofplateletfactor3activityinvitroandinvivo

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