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ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET

Albino rats maintained for 50 to 60 days on rations containing cholesterol, sodium cholate, and thiouracil were found to be highly susceptible to the lethal effects of infection with Mycobacterium tuberculosis. Maximum loss of resistance occurred only when all three components were present in a sing...

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Detalles Bibliográficos
Autores principales: Costello, Richard L., Hedgecock, Loyd W., Hamilton, Tom R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137583/
https://www.ncbi.nlm.nih.gov/pubmed/14023314
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author Costello, Richard L.
Hedgecock, Loyd W.
Hamilton, Tom R.
author_facet Costello, Richard L.
Hedgecock, Loyd W.
Hamilton, Tom R.
author_sort Costello, Richard L.
collection PubMed
description Albino rats maintained for 50 to 60 days on rations containing cholesterol, sodium cholate, and thiouracil were found to be highly susceptible to the lethal effects of infection with Mycobacterium tuberculosis. Maximum loss of resistance occurred only when all three components were present in a single ration. A lesser degree of susceptibility resulted from the deletion of one or more of the factors from the diet. Animals maintained on control rations never died of the infection. Histopathological studies of stained sections of tissues of infected animals revealed that the reaction of the host to the bacillus was more extensive and less well contained in animals fed the complete atherogenic ration than in the controls.
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spelling pubmed-21375832008-04-17 ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET Costello, Richard L. Hedgecock, Loyd W. Hamilton, Tom R. J Exp Med Article Albino rats maintained for 50 to 60 days on rations containing cholesterol, sodium cholate, and thiouracil were found to be highly susceptible to the lethal effects of infection with Mycobacterium tuberculosis. Maximum loss of resistance occurred only when all three components were present in a single ration. A lesser degree of susceptibility resulted from the deletion of one or more of the factors from the diet. Animals maintained on control rations never died of the infection. Histopathological studies of stained sections of tissues of infected animals revealed that the reaction of the host to the bacillus was more extensive and less well contained in animals fed the complete atherogenic ration than in the controls. The Rockefeller University Press 1962-11-30 /pmc/articles/PMC2137583/ /pubmed/14023314 Text en ©Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Costello, Richard L.
Hedgecock, Loyd W.
Hamilton, Tom R.
ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title_full ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title_fullStr ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title_full_unstemmed ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title_short ALTERATION OF RESISTANCE OF THE RAT TO TUBERCULOSIS WHEN MAINTAINED ON AN ATHEROGENIC DIET
title_sort alteration of resistance of the rat to tuberculosis when maintained on an atherogenic diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137583/
https://www.ncbi.nlm.nih.gov/pubmed/14023314
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