EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT

The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization...

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Detalles Bibliográficos
Autores principales: Hammer, Dietrich K., Dixon, Frank J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137595/
https://www.ncbi.nlm.nih.gov/pubmed/13952379
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author Hammer, Dietrich K.
Dixon, Frank J.
author_facet Hammer, Dietrich K.
Dixon, Frank J.
author_sort Hammer, Dietrich K.
collection PubMed
description The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization of or dependence upon serum complement. The secondary phase of nephrotoxic serum nephritis appears to be largely or entirely dependent upon the host's antibody response to the heterologous gamma globulin fixed in the glomeruli. No evidence could be obtained for the existence of an autoimmune antikidney response by the host in this experimental model.
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spelling pubmed-21375952008-04-17 EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT Hammer, Dietrich K. Dixon, Frank J. J Exp Med Article The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization of or dependence upon serum complement. The secondary phase of nephrotoxic serum nephritis appears to be largely or entirely dependent upon the host's antibody response to the heterologous gamma globulin fixed in the glomeruli. No evidence could be obtained for the existence of an autoimmune antikidney response by the host in this experimental model. The Rockefeller University Press 1963-06-01 /pmc/articles/PMC2137595/ /pubmed/13952379 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hammer, Dietrich K.
Dixon, Frank J.
EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title_full EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title_fullStr EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title_full_unstemmed EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title_short EXPERIMENTAL GLOMERULONEPHRITIS : II. IMMUNOLOGIC EVENTS IN THE PATHOGENESIS OF NEPHROTOXIC SERUM NEPHRITIS IN THE RAT
title_sort experimental glomerulonephritis : ii. immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137595/
https://www.ncbi.nlm.nih.gov/pubmed/13952379
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