STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE

Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measura...

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Detalles Bibliográficos
Autores principales: O'Brien, Thomas F., Coons, Albert H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137596/
https://www.ncbi.nlm.nih.gov/pubmed/19867230
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author O'Brien, Thomas F.
Coons, Albert H.
author_facet O'Brien, Thomas F.
Coons, Albert H.
author_sort O'Brien, Thomas F.
collection PubMed
description Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period.
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spelling pubmed-21375962008-04-17 STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE O'Brien, Thomas F. Coons, Albert H. J Exp Med Article Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period. The Rockefeller University Press 1963-06-01 /pmc/articles/PMC2137596/ /pubmed/19867230 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
O'Brien, Thomas F.
Coons, Albert H.
STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title_full STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title_fullStr STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title_full_unstemmed STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title_short STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE
title_sort studies on antibody production : vii. the effect of 5-bromodeoxyuridine on the in vitro anamnestic antibody response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137596/
https://www.ncbi.nlm.nih.gov/pubmed/19867230
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