STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO

The in vitro anamnestic antibody response of popliteal lymph node fragments to additions of antigen closely resembles the in vivo anamnestic antibody response in its sensitivity to antigen, in the time course of antibody production, and in the sequence of appearance and the morphology of the antibod...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Brien, Thomas F., Michaelides, Maria C., Coons, Albert H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137598/
https://www.ncbi.nlm.nih.gov/pubmed/19867229
_version_ 1782143369414180864
author O'Brien, Thomas F.
Michaelides, Maria C.
Coons, Albert H.
author_facet O'Brien, Thomas F.
Michaelides, Maria C.
Coons, Albert H.
author_sort O'Brien, Thomas F.
collection PubMed
description The in vitro anamnestic antibody response of popliteal lymph node fragments to additions of antigen closely resembles the in vivo anamnestic antibody response in its sensitivity to antigen, in the time course of antibody production, and in the sequence of appearance and the morphology of the antibody containing cells. Most of the cells responsible for antibody synthesis remain in the explant and do not migrate, although a few can be found in the outgrowing sheet of cells. The smallest concentration of bovine serum albumin which stimulates an anamnestic response in vitro is about 1 x 10(–9) gm/ml.
format Text
id pubmed-2137598
institution National Center for Biotechnology Information
language English
publishDate 1963
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21375982008-04-17 STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO O'Brien, Thomas F. Michaelides, Maria C. Coons, Albert H. J Exp Med Article The in vitro anamnestic antibody response of popliteal lymph node fragments to additions of antigen closely resembles the in vivo anamnestic antibody response in its sensitivity to antigen, in the time course of antibody production, and in the sequence of appearance and the morphology of the antibody containing cells. Most of the cells responsible for antibody synthesis remain in the explant and do not migrate, although a few can be found in the outgrowing sheet of cells. The smallest concentration of bovine serum albumin which stimulates an anamnestic response in vitro is about 1 x 10(–9) gm/ml. The Rockefeller University Press 1963-06-01 /pmc/articles/PMC2137598/ /pubmed/19867229 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
O'Brien, Thomas F.
Michaelides, Maria C.
Coons, Albert H.
STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title_full STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title_fullStr STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title_full_unstemmed STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title_short STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
title_sort studies on antibody production : vi. the course, sensitivity, and histology of the secondary response in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137598/
https://www.ncbi.nlm.nih.gov/pubmed/19867229
work_keys_str_mv AT obrienthomasf studiesonantibodyproductionvithecoursesensitivityandhistologyofthesecondaryresponseinvitro
AT michaelidesmariac studiesonantibodyproductionvithecoursesensitivityandhistologyofthesecondaryresponseinvitro
AT coonsalberth studiesonantibodyproductionvithecoursesensitivityandhistologyofthesecondaryresponseinvitro

Ejemplares similares