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PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
Guinea pig 7Sγ(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1963
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137601/ https://www.ncbi.nlm.nih.gov/pubmed/13940786 |
| Sumario: | Guinea pig 7Sγ(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites. |
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