ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS

It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effectiv...

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Detalles Bibliográficos
Autores principales: Maurer, Paul H., Gerulat, Bernard F., Pinchuck, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1962
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137629/
https://www.ncbi.nlm.nih.gov/pubmed/13933994
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author Maurer, Paul H.
Gerulat, Bernard F.
Pinchuck, Paul
author_facet Maurer, Paul H.
Gerulat, Bernard F.
Pinchuck, Paul
author_sort Maurer, Paul H.
collection PubMed
description It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis. The immediate skin reactivity appeared not to be related to the P-K antibody. The delayed reaction was histologically distinct from the immediate reaction and consisted of perivascular lymphocytic infiltration in contrast to the predominantly polymorphonuclear cells in the latter reaction. The antigenic response against the polymers resembled that observed with proteins. From cross-reactions it appears that the response is heterogeneous in the sense that not all individuals react against the same groupings in the complex polymers.
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spelling pubmed-21376292008-04-17 ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS Maurer, Paul H. Gerulat, Bernard F. Pinchuck, Paul J Exp Med Article It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis. The immediate skin reactivity appeared not to be related to the P-K antibody. The delayed reaction was histologically distinct from the immediate reaction and consisted of perivascular lymphocytic infiltration in contrast to the predominantly polymorphonuclear cells in the latter reaction. The antigenic response against the polymers resembled that observed with proteins. From cross-reactions it appears that the response is heterogeneous in the sense that not all individuals react against the same groupings in the complex polymers. The Rockefeller University Press 1962-10-01 /pmc/articles/PMC2137629/ /pubmed/13933994 Text en ©Copyright, 1962, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Maurer, Paul H.
Gerulat, Bernard F.
Pinchuck, Paul
ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title_full ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title_fullStr ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title_full_unstemmed ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title_short ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : VII. STUDIES IN HUMANS
title_sort antigenicity of polypeptides (poly alpha amino acids) : vii. studies in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137629/
https://www.ncbi.nlm.nih.gov/pubmed/13933994
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