RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS

Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization....

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Detalles Bibliográficos
Autor principal: Cotran, Ramzi S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137638/
https://www.ncbi.nlm.nih.gov/pubmed/14023347
Descripción
Sumario:Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization. Persistent antigen was associated with interstitial chronic inflammation but not with acute inflammation or progressive scarring. Rat gamma globulin and proteus antibody were localized in plasma cells of the renal inflammatory infiltrates. It is suggested that persistent antigen in chronic pyelonephritis may lead to the continued local appearance of antibody-producing cells.

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