RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS

Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization....

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Detalles Bibliográficos
Autor principal: Cotran, Ramzi S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137638/
https://www.ncbi.nlm.nih.gov/pubmed/14023347
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author Cotran, Ramzi S.
author_facet Cotran, Ramzi S.
author_sort Cotran, Ramzi S.
collection PubMed
description Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization. Persistent antigen was associated with interstitial chronic inflammation but not with acute inflammation or progressive scarring. Rat gamma globulin and proteus antibody were localized in plasma cells of the renal inflammatory infiltrates. It is suggested that persistent antigen in chronic pyelonephritis may lead to the continued local appearance of antibody-producing cells.
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spelling pubmed-21376382008-04-17 RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS Cotran, Ramzi S. J Exp Med Article Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization. Persistent antigen was associated with interstitial chronic inflammation but not with acute inflammation or progressive scarring. Rat gamma globulin and proteus antibody were localized in plasma cells of the renal inflammatory infiltrates. It is suggested that persistent antigen in chronic pyelonephritis may lead to the continued local appearance of antibody-producing cells. The Rockefeller University Press 1963-05-01 /pmc/articles/PMC2137638/ /pubmed/14023347 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Cotran, Ramzi S.
RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title_full RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title_fullStr RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title_full_unstemmed RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title_short RETROGRADE PROTEUS PYELONEPHRITIS IN RATS : LOCALIZATION OF ANTIGEN AND ANTIBODY IN TREATED STERILE PYELONEPHRITIC KIDNEYS
title_sort retrograde proteus pyelonephritis in rats : localization of antigen and antibody in treated sterile pyelonephritic kidneys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137638/
https://www.ncbi.nlm.nih.gov/pubmed/14023347
work_keys_str_mv AT cotranramzis retrogradeproteuspyelonephritisinratslocalizationofantigenandantibodyintreatedsterilepyelonephritickidneys

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