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ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION
Enhancement and acceleration of the antibody response can be achieved in some situations with large, cytotoxic doses of whole body x-radiation given after antigenic stimulation. The timing of radiation is critical and varies with the kind and physical form of the antigen. It is postulated that the x...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1963
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137642/ https://www.ncbi.nlm.nih.gov/pubmed/14028123 |
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author | Dixon, Frank J. McConahey, Patricia J. |
author_facet | Dixon, Frank J. McConahey, Patricia J. |
author_sort | Dixon, Frank J. |
collection | PubMed |
description | Enhancement and acceleration of the antibody response can be achieved in some situations with large, cytotoxic doses of whole body x-radiation given after antigenic stimulation. The timing of radiation is critical and varies with the kind and physical form of the antigen. It is postulated that the x-radiation depletes the cells of the lymphoid tissues just prior to the rapid proliferation of the antigen stimulated cells. In this situation those surviving cells which are stimulated by antigen multiply more rapidly than their non-stimulated counterparts and disproportionately repopulate the depleted lymphoid tissues. Whether the x-radiation produces other effects contributing to the multiplication of the antibody forming cells was not determined. It appears that x-radiation produces its enhancement of antibody formation by means different from those operating in endotoxin and colchicine induced enhancement. |
format | Text |
id | pubmed-2137642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1963 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21376422008-04-17 ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION Dixon, Frank J. McConahey, Patricia J. J Exp Med Article Enhancement and acceleration of the antibody response can be achieved in some situations with large, cytotoxic doses of whole body x-radiation given after antigenic stimulation. The timing of radiation is critical and varies with the kind and physical form of the antigen. It is postulated that the x-radiation depletes the cells of the lymphoid tissues just prior to the rapid proliferation of the antigen stimulated cells. In this situation those surviving cells which are stimulated by antigen multiply more rapidly than their non-stimulated counterparts and disproportionately repopulate the depleted lymphoid tissues. Whether the x-radiation produces other effects contributing to the multiplication of the antibody forming cells was not determined. It appears that x-radiation produces its enhancement of antibody formation by means different from those operating in endotoxin and colchicine induced enhancement. The Rockefeller University Press 1963-05-01 /pmc/articles/PMC2137642/ /pubmed/14028123 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Dixon, Frank J. McConahey, Patricia J. ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title | ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title_full | ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title_fullStr | ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title_full_unstemmed | ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title_short | ENHANCEMENT OF ANTIBODY FORMATION BY WHOLE BODY X-RADIATION |
title_sort | enhancement of antibody formation by whole body x-radiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137642/ https://www.ncbi.nlm.nih.gov/pubmed/14028123 |
work_keys_str_mv | AT dixonfrankj enhancementofantibodyformationbywholebodyxradiation AT mcconaheypatriciaj enhancementofantibodyformationbywholebodyxradiation |