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STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA
The various cellular components of immune rabbit histiocytes have been analyzed for their ability to induce cellular resistance in normal animals. The results of these investigations have shown that the nuclear and mitochondrial fractions were inactive and that the microsomal and ribosomal fractions...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1963
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137647/ https://www.ncbi.nlm.nih.gov/pubmed/14077998 |
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author | Fong, Jacob Chin, Dennis Elberg, Sanford S. |
author_facet | Fong, Jacob Chin, Dennis Elberg, Sanford S. |
author_sort | Fong, Jacob |
collection | PubMed |
description | The various cellular components of immune rabbit histiocytes have been analyzed for their ability to induce cellular resistance in normal animals. The results of these investigations have shown that the nuclear and mitochondrial fractions were inactive and that the microsomal and ribosomal fractions were active. The importance of ribonucleic acid in induction of cellular resistance was established by isolation of an active ribosomal RNA and by demonstration of inactivation of this material with ribonuclease but not with deoxyribonuclease or trypsin. The possibility that viable bacilli were present in immune ribosomes was tested; the absence of complement-fixing antibodies and of skin reactivity to tuberculin in animals inoculated with ribosomes was considered as partial evidence of absence of living bacilli. |
format | Text |
id | pubmed-2137647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1963 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21376472008-04-17 STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA Fong, Jacob Chin, Dennis Elberg, Sanford S. J Exp Med Article The various cellular components of immune rabbit histiocytes have been analyzed for their ability to induce cellular resistance in normal animals. The results of these investigations have shown that the nuclear and mitochondrial fractions were inactive and that the microsomal and ribosomal fractions were active. The importance of ribonucleic acid in induction of cellular resistance was established by isolation of an active ribosomal RNA and by demonstration of inactivation of this material with ribonuclease but not with deoxyribonuclease or trypsin. The possibility that viable bacilli were present in immune ribosomes was tested; the absence of complement-fixing antibodies and of skin reactivity to tuberculin in animals inoculated with ribosomes was considered as partial evidence of absence of living bacilli. The Rockefeller University Press 1963-09-01 /pmc/articles/PMC2137647/ /pubmed/14077998 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Fong, Jacob Chin, Dennis Elberg, Sanford S. STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title | STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title_full | STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title_fullStr | STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title_full_unstemmed | STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title_short | STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS : VI. INDUCTION OF CELLULAR RESISTANCE BY RIBOSOMES AND RIBOSOMAL RNA |
title_sort | studies of tubercle bacillus-histiocyte relationships : vi. induction of cellular resistance by ribosomes and ribosomal rna |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137647/ https://www.ncbi.nlm.nih.gov/pubmed/14077998 |
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