ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS

The fine structure of collagen fibrils at sites of antigen-antibody interaction is described. Following injection of antigen (BSA or ferritin) into the center of the cornea of hyperimmune rabbits, an acidophilic ring of precipitate forms at the periphery of the cornea, where antigen and antibody int...

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Detalles Bibliográficos
Autores principales: Movat, Henry Z., Fernando, Neil V. P., Uriuhara, Tsuneo, Weiser, William J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137660/
https://www.ncbi.nlm.nih.gov/pubmed/14067905
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author Movat, Henry Z.
Fernando, Neil V. P.
Uriuhara, Tsuneo
Weiser, William J.
author_facet Movat, Henry Z.
Fernando, Neil V. P.
Uriuhara, Tsuneo
Weiser, William J.
author_sort Movat, Henry Z.
collection PubMed
description The fine structure of collagen fibrils at sites of antigen-antibody interaction is described. Following injection of antigen (BSA or ferritin) into the center of the cornea of hyperimmune rabbits, an acidophilic ring of precipitate forms at the periphery of the cornea, where antigen and antibody interact in optimal proportions. The precipitate is soon removed by infiltrating polymorphs, but persists longer in leukopenic animals. Electron microscopic examination of the cornea showed no alteration of the collagen fibrils in the area of antigen-antibody precipitation or in the remaining cornea. Contrary to many claims there was no swelling, fragmentation, or disintegration of the fibrils and they had a normal periodicity. Polymorphs infiltrated the precipitates and phagocytosed the antigen-antibody complexes. There was some ultrastructural evidence that degradation of the complexes took place in the polymorphs.
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spelling pubmed-21376602008-04-17 ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS Movat, Henry Z. Fernando, Neil V. P. Uriuhara, Tsuneo Weiser, William J. J Exp Med Article The fine structure of collagen fibrils at sites of antigen-antibody interaction is described. Following injection of antigen (BSA or ferritin) into the center of the cornea of hyperimmune rabbits, an acidophilic ring of precipitate forms at the periphery of the cornea, where antigen and antibody interact in optimal proportions. The precipitate is soon removed by infiltrating polymorphs, but persists longer in leukopenic animals. Electron microscopic examination of the cornea showed no alteration of the collagen fibrils in the area of antigen-antibody precipitation or in the remaining cornea. Contrary to many claims there was no swelling, fragmentation, or disintegration of the fibrils and they had a normal periodicity. Polymorphs infiltrated the precipitates and phagocytosed the antigen-antibody complexes. There was some ultrastructural evidence that degradation of the complexes took place in the polymorphs. The Rockefeller University Press 1963-10-01 /pmc/articles/PMC2137660/ /pubmed/14067905 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Movat, Henry Z.
Fernando, Neil V. P.
Uriuhara, Tsuneo
Weiser, William J.
ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title_full ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title_fullStr ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title_full_unstemmed ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title_short ALLERGIC INFLAMMATION : III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS
title_sort allergic inflammation : iii. the fine structure of collagen fibrils at sites of antigen-antibody interaction in arthus-type lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137660/
https://www.ncbi.nlm.nih.gov/pubmed/14067905
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