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ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating,...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1963
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137662/ https://www.ncbi.nlm.nih.gov/pubmed/14067909 |
| Sumario: | "Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of γ(2)-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin. |
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