ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS

"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating,...

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Detalles Bibliográficos
Autores principales: Michael, J. Gabriel, Rosen, Fred S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137662/
https://www.ncbi.nlm.nih.gov/pubmed/14067909
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author Michael, J. Gabriel
Rosen, Fred S.
author_facet Michael, J. Gabriel
Rosen, Fred S.
author_sort Michael, J. Gabriel
collection PubMed
description "Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of γ(2)-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.
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spelling pubmed-21376622008-04-17 ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS Michael, J. Gabriel Rosen, Fred S. J Exp Med Article "Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of γ(2)-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin. The Rockefeller University Press 1963-10-01 /pmc/articles/PMC2137662/ /pubmed/14067909 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Michael, J. Gabriel
Rosen, Fred S.
ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title_full ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title_fullStr ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title_full_unstemmed ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title_short ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ(1)-MACROGLOBULINS
title_sort association of "natural" antibodies to gram-negative bacteria with the γ(1)-macroglobulins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137662/
https://www.ncbi.nlm.nih.gov/pubmed/14067909
work_keys_str_mv AT michaeljgabriel associationofnaturalantibodiestogramnegativebacteriawiththeg1macroglobulins
AT rosenfreds associationofnaturalantibodiestogramnegativebacteriawiththeg1macroglobulins

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