CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN

Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extr...

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Detalles Bibliográficos
Autores principales: Van den Bosch, Jozef, Billiau, Alfons
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137664/
https://www.ncbi.nlm.nih.gov/pubmed/14067903
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author Van den Bosch, Jozef
Billiau, Alfons
author_facet Van den Bosch, Jozef
Billiau, Alfons
author_sort Van den Bosch, Jozef
collection PubMed
description Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive syndrome, but not in animals that received the detergent. The mechanism of the convulsions probably includes the toxicity of high amounts of non-esterified fatty acids.
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spelling pubmed-21376642008-04-17 CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN Van den Bosch, Jozef Billiau, Alfons J Exp Med Article Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive syndrome, but not in animals that received the detergent. The mechanism of the convulsions probably includes the toxicity of high amounts of non-esterified fatty acids. The Rockefeller University Press 1963-10-01 /pmc/articles/PMC2137664/ /pubmed/14067903 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Van den Bosch, Jozef
Billiau, Alfons
CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title_full CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title_fullStr CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title_full_unstemmed CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title_short CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN
title_sort convulsive syndrome in rabbits injected with fat emulsion and heparin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137664/
https://www.ncbi.nlm.nih.gov/pubmed/14067903
work_keys_str_mv AT vandenboschjozef convulsivesyndromeinrabbitsinjectedwithfatemulsionandheparin
AT billiaualfons convulsivesyndromeinrabbitsinjectedwithfatemulsionandheparin

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