STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS

The genetic transmission of the capacity to develop an immune response to hapten-polylysine conjugates was studied in guinea pigs. 82 per cent of the 22 offspring of 8 pairs of responder (guinea pigs which are capable of an immune response) parents were also responders, whereas, none of the 26 offsp...

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Detalles Bibliográficos
Autores principales: Levine, Bernard B., Ojeda, Antonio, Benacerraf, Baruj
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137686/
https://www.ncbi.nlm.nih.gov/pubmed/14112274
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author Levine, Bernard B.
Ojeda, Antonio
Benacerraf, Baruj
author_facet Levine, Bernard B.
Ojeda, Antonio
Benacerraf, Baruj
author_sort Levine, Bernard B.
collection PubMed
description The genetic transmission of the capacity to develop an immune response to hapten-polylysine conjugates was studied in guinea pigs. 82 per cent of the 22 offspring of 8 pairs of responder (guinea pigs which are capable of an immune response) parents were also responders, whereas, none of the 26 offspring of 9 pairs of non-responder parents were responders. None of 11 strain 13 guinea pigs and 100 per cent of 40 strain 2 guinea pigs were responders. These findings are consistent with the view that the capacity to respond immunologically to hapten-polylysine conjugates is genetically transmitted as a unigenic Mendelian dominant.
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spelling pubmed-21376862008-04-17 STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS Levine, Bernard B. Ojeda, Antonio Benacerraf, Baruj J Exp Med Article The genetic transmission of the capacity to develop an immune response to hapten-polylysine conjugates was studied in guinea pigs. 82 per cent of the 22 offspring of 8 pairs of responder (guinea pigs which are capable of an immune response) parents were also responders, whereas, none of the 26 offspring of 9 pairs of non-responder parents were responders. None of 11 strain 13 guinea pigs and 100 per cent of 40 strain 2 guinea pigs were responders. These findings are consistent with the view that the capacity to respond immunologically to hapten-polylysine conjugates is genetically transmitted as a unigenic Mendelian dominant. The Rockefeller University Press 1963-11-30 /pmc/articles/PMC2137686/ /pubmed/14112274 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Levine, Bernard B.
Ojeda, Antonio
Benacerraf, Baruj
STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title_full STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title_fullStr STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title_full_unstemmed STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title_short STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS
title_sort studies on artificial antigens : iii. the genetic control of the immune response to hapten-poly-l-lysine conjugates in guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137686/
https://www.ncbi.nlm.nih.gov/pubmed/14112274
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AT benacerrafbaruj studiesonartificialantigensiiithegeneticcontroloftheimmuneresponsetohaptenpolyllysineconjugatesinguineapigs

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