THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY

A close inomunochemical relationship of Forssman-type antigens in cells or in a methanol extract of guinea pig kidneys, lymph nodes, and platelets, of horse kidneys, and of sheep erythrocytes was demonstrated by complement-fixation, agglutination, and inhibition of hemolysis. The dissociation of ant...

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Detalles Bibliográficos
Autores principales: Fujii, Genshichiro, Nelson, Robert A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137699/
https://www.ncbi.nlm.nih.gov/pubmed/14112264
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author Fujii, Genshichiro
Nelson, Robert A.
author_facet Fujii, Genshichiro
Nelson, Robert A.
author_sort Fujii, Genshichiro
collection PubMed
description A close inomunochemical relationship of Forssman-type antigens in cells or in a methanol extract of guinea pig kidneys, lymph nodes, and platelets, of horse kidneys, and of sheep erythrocytes was demonstrated by complement-fixation, agglutination, and inhibition of hemolysis. The dissociation of antibody from several cross-reacting complexes and re-association with antigens of erythrocytes used for immunization was inferred from quantitative hemolytic assays. This preferential affinity of antibody for the antigen used for immunization is proposed as an immunochemical model for reactions which function in graft rejection phenomena wherein the donor and recipient tissues share cross-reacting antigens.
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spelling pubmed-21376992008-04-17 THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY Fujii, Genshichiro Nelson, Robert A. J Exp Med Article A close inomunochemical relationship of Forssman-type antigens in cells or in a methanol extract of guinea pig kidneys, lymph nodes, and platelets, of horse kidneys, and of sheep erythrocytes was demonstrated by complement-fixation, agglutination, and inhibition of hemolysis. The dissociation of antibody from several cross-reacting complexes and re-association with antigens of erythrocytes used for immunization was inferred from quantitative hemolytic assays. This preferential affinity of antibody for the antigen used for immunization is proposed as an immunochemical model for reactions which function in graft rejection phenomena wherein the donor and recipient tissues share cross-reacting antigens. The Rockefeller University Press 1963-11-30 /pmc/articles/PMC2137699/ /pubmed/14112264 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fujii, Genshichiro
Nelson, Robert A.
THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title_full THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title_fullStr THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title_full_unstemmed THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title_short THE CROSS-REACTIVITY AND TRANSFER OF ANTIBODY IN TRANSPLANTATION IMMUNITY
title_sort cross-reactivity and transfer of antibody in transplantation immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137699/
https://www.ncbi.nlm.nih.gov/pubmed/14112264
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