STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS

An effort was made to immunize guinea pigs with arsanilic acid conjugates of copolymers of D- and L-α-amino acids; ASD-GAT and ASL-GAT. An immune response was observed only in the case of ASL-GAT. Antibodies specific for the arsanilic acid hapten were produced which could also react with ASD-GAT or...

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Detalles Bibliográficos
Autores principales: Benacerraf, Baruj, Ojeda, Antonio, Maurer, Paul H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137701/
https://www.ncbi.nlm.nih.gov/pubmed/14112273
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author Benacerraf, Baruj
Ojeda, Antonio
Maurer, Paul H.
author_facet Benacerraf, Baruj
Ojeda, Antonio
Maurer, Paul H.
author_sort Benacerraf, Baruj
collection PubMed
description An effort was made to immunize guinea pigs with arsanilic acid conjugates of copolymers of D- and L-α-amino acids; ASD-GAT and ASL-GAT. An immune response was observed only in the case of ASL-GAT. Antibodies specific for the arsanilic acid hapten were produced which could also react with ASD-GAT or ASGPA. These findings indicate that the proper metabolism of the antigen may be essential to the induction of the immune response.
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spelling pubmed-21377012008-04-17 STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS Benacerraf, Baruj Ojeda, Antonio Maurer, Paul H. J Exp Med Article An effort was made to immunize guinea pigs with arsanilic acid conjugates of copolymers of D- and L-α-amino acids; ASD-GAT and ASL-GAT. An immune response was observed only in the case of ASL-GAT. Antibodies specific for the arsanilic acid hapten were produced which could also react with ASD-GAT or ASGPA. These findings indicate that the proper metabolism of the antigen may be essential to the induction of the immune response. The Rockefeller University Press 1963-11-30 /pmc/articles/PMC2137701/ /pubmed/14112273 Text en Copyright © 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Benacerraf, Baruj
Ojeda, Antonio
Maurer, Paul H.
STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title_full STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title_fullStr STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title_full_unstemmed STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title_short STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS
title_sort studies on artificial antigens : ii. the antigenicity in guinea pigs of arsanilic acid conjugates of copolymers of d- or l-α-amino acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137701/
https://www.ncbi.nlm.nih.gov/pubmed/14112273
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