HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM

Heterogeneity of the group-specific (Gc) components in normal human serum has been demonstrated by the use of a lithium borate buffer system in conventional vertical starch gel electrophoresis and by prolonged immunoelectrophoresis in agar gel. In both Gc 1-1 and Gc 2-2 phenotypes a protein componen...

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Detalles Bibliográficos
Autores principales: Bearn, Alexander G., Kitchin, F. David, Bowman, Barbara H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137722/
https://www.ncbi.nlm.nih.gov/pubmed/14194394
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author Bearn, Alexander G.
Kitchin, F. David
Bowman, Barbara H.
author_facet Bearn, Alexander G.
Kitchin, F. David
Bowman, Barbara H.
author_sort Bearn, Alexander G.
collection PubMed
description Heterogeneity of the group-specific (Gc) components in normal human serum has been demonstrated by the use of a lithium borate buffer system in conventional vertical starch gel electrophoresis and by prolonged immunoelectrophoresis in agar gel. In both Gc 1-1 and Gc 2-2 phenotypes a protein component migrates ahead of the main band. Immunological evidence indicates that the faster migrating band contains Gc specificity. The possibility that the two electrophoretically distinct Gc components share a common polypeptide chain is discussed.
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spelling pubmed-21377222008-04-17 HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM Bearn, Alexander G. Kitchin, F. David Bowman, Barbara H. J Exp Med Article Heterogeneity of the group-specific (Gc) components in normal human serum has been demonstrated by the use of a lithium borate buffer system in conventional vertical starch gel electrophoresis and by prolonged immunoelectrophoresis in agar gel. In both Gc 1-1 and Gc 2-2 phenotypes a protein component migrates ahead of the main band. Immunological evidence indicates that the faster migrating band contains Gc specificity. The possibility that the two electrophoretically distinct Gc components share a common polypeptide chain is discussed. The Rockefeller University Press 1964-07-01 /pmc/articles/PMC2137722/ /pubmed/14194394 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bearn, Alexander G.
Kitchin, F. David
Bowman, Barbara H.
HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title_full HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title_fullStr HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title_full_unstemmed HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title_short HETEROGENEITY OF THE INHERITED GROUP-SPECIFIC COMPONENT OF HUMAN SERUM
title_sort heterogeneity of the inherited group-specific component of human serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137722/
https://www.ncbi.nlm.nih.gov/pubmed/14194394
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AT kitchinfdavid heterogeneityoftheinheritedgroupspecificcomponentofhumanserum
AT bowmanbarbarah heterogeneityoftheinheritedgroupspecificcomponentofhumanserum

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