EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN

The platelet injury produced by bacterial endotoxin and thrombin have been compared in studies utilizing citrated rabbit platelet-rich plasma. Endotoxin-induced platelet injury is characterized by a lag period, is progressive, and does not produce gross clot formation. Thrombin-induced platelet inju...

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Detalles Bibliográficos
Autor principal: Des Prez, Roger M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137729/
https://www.ncbi.nlm.nih.gov/pubmed/14208251
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author Des Prez, Roger M.
author_facet Des Prez, Roger M.
author_sort Des Prez, Roger M.
collection PubMed
description The platelet injury produced by bacterial endotoxin and thrombin have been compared in studies utilizing citrated rabbit platelet-rich plasma. Endotoxin-induced platelet injury is characterized by a lag period, is progressive, and does not produce gross clot formation. Thrombin-induced platelet injury is immediate, non-progressive, and is associated with clot formation. The quantity of thrombin required to produce clot formation in this citrated system is less than that required to produce release of platelet 5-hydroxytryptamine. The endotoxin-induced platelet injury required extremely large quantities of heparin for inhibition. The platelet injury induced by thrombin can be inhibited by small quantities of heparin. It is concluded that the injurious effects of endotoxin on platelets is mediated through some mechanism other than thrombin formation.
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spelling pubmed-21377292008-04-17 EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN Des Prez, Roger M. J Exp Med Article The platelet injury produced by bacterial endotoxin and thrombin have been compared in studies utilizing citrated rabbit platelet-rich plasma. Endotoxin-induced platelet injury is characterized by a lag period, is progressive, and does not produce gross clot formation. Thrombin-induced platelet injury is immediate, non-progressive, and is associated with clot formation. The quantity of thrombin required to produce clot formation in this citrated system is less than that required to produce release of platelet 5-hydroxytryptamine. The endotoxin-induced platelet injury required extremely large quantities of heparin for inhibition. The platelet injury induced by thrombin can be inhibited by small quantities of heparin. It is concluded that the injurious effects of endotoxin on platelets is mediated through some mechanism other than thrombin formation. The Rockefeller University Press 1964-08-01 /pmc/articles/PMC2137729/ /pubmed/14208251 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Des Prez, Roger M.
EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title_full EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title_fullStr EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title_full_unstemmed EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title_short EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
title_sort effects of bacterial endotoxin on rabbit platelets : iii. comparison of platelet injury induced by thrombin and by endotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137729/
https://www.ncbi.nlm.nih.gov/pubmed/14208251
work_keys_str_mv AT desprezrogerm effectsofbacterialendotoxinonrabbitplateletsiiicomparisonofplateletinjuryinducedbythrombinandbyendotoxin

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