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SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL

Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administ...

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Detalles Bibliográficos
Autores principales: Weisberger, Austin S., Daniel, Thomas M., Hoffman, Allan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137731/
https://www.ncbi.nlm.nih.gov/pubmed/19867290
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author Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
author_facet Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
author_sort Weisberger, Austin S.
collection PubMed
description Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administered. The mechanism of action of chloramphenicol in suppressing immune responses is correlated with its ability to inhibit protein synthesis in proliferating mammalian cells. These observations suggest that the inhibitory effect of chloramphenicol on protein synthesis may be applicable to mammalian cells in vivo as well as to cell-free systems and to intact mammalian cells in vivo.
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spelling pubmed-21377312008-04-17 SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL Weisberger, Austin S. Daniel, Thomas M. Hoffman, Allan J Exp Med Article Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administered. The mechanism of action of chloramphenicol in suppressing immune responses is correlated with its ability to inhibit protein synthesis in proliferating mammalian cells. These observations suggest that the inhibitory effect of chloramphenicol on protein synthesis may be applicable to mammalian cells in vivo as well as to cell-free systems and to intact mammalian cells in vivo. The Rockefeller University Press 1964-08-01 /pmc/articles/PMC2137731/ /pubmed/19867290 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_full SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_fullStr SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_full_unstemmed SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_short SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_sort suppression of antibody synthesis and prolongation of homograft survival by chloramphenicol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137731/
https://www.ncbi.nlm.nih.gov/pubmed/19867290
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