THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS

Two subclasses of mouse 7S γ(2)-globulins are identified, and are designated γ(2a)- and γ(2b)-globulins. They are distinguished from 7S γ(1)-globulins, γ(1A) (β(2A))-globulins, and γ(1M)-globulins of mouse serum. Antibody activity was detected among the γ(2a)-globulins and γ(2b)-globulins of hyperim...

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Detalles Bibliográficos
Autores principales: Fahey, John L., Wunderlich, John, Mishell, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137737/
https://www.ncbi.nlm.nih.gov/pubmed/14206439
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author Fahey, John L.
Wunderlich, John
Mishell, Robert
author_facet Fahey, John L.
Wunderlich, John
Mishell, Robert
author_sort Fahey, John L.
collection PubMed
description Two subclasses of mouse 7S γ(2)-globulins are identified, and are designated γ(2a)- and γ(2b)-globulins. They are distinguished from 7S γ(1)-globulins, γ(1A) (β(2A))-globulins, and γ(1M)-globulins of mouse serum. Antibody activity was detected among the γ(2a)-globulins and γ(2b)-globulins of hyperimmune mouse serum. γ(2a)- and γ(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on γ(2a)-myeloma proteins, but not on γ(2b)-myeloma proteins. These findings indicate a complexity among the 7S γ(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.
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spelling pubmed-21377372008-04-17 THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS Fahey, John L. Wunderlich, John Mishell, Robert J Exp Med Article Two subclasses of mouse 7S γ(2)-globulins are identified, and are designated γ(2a)- and γ(2b)-globulins. They are distinguished from 7S γ(1)-globulins, γ(1A) (β(2A))-globulins, and γ(1M)-globulins of mouse serum. Antibody activity was detected among the γ(2a)-globulins and γ(2b)-globulins of hyperimmune mouse serum. γ(2a)- and γ(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on γ(2a)-myeloma proteins, but not on γ(2b)-myeloma proteins. These findings indicate a complexity among the 7S γ(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins. The Rockefeller University Press 1964-08-01 /pmc/articles/PMC2137737/ /pubmed/14206439 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fahey, John L.
Wunderlich, John
Mishell, Robert
THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title_full THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title_fullStr THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title_full_unstemmed THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title_short THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ(2)-GLOBULINS: γ(2a(-))ANDγ(2b)-GLOBULINS
title_sort immunoglobulins of mice : ii. two subclasses of mouse 7s γ(2)-globulins: γ(2a(-))andγ(2b)-globulins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137737/
https://www.ncbi.nlm.nih.gov/pubmed/14206439
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