THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS

Adult guinea pigs were made unresponsive to a heterologous protein (e.g. bovine gamma globulin, or BGG) or a hapten-protein conjugate (e.g. p-aminobenzoic acid-bovine gamma globulin, or PABAγmiddot;BGG) by intraperitoneal injection of 80 mg cyclophosphamide and the specific antigen. This immunologic...

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Detalles Bibliográficos
Autores principales: Salvin, S. B., Smith, R. F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137739/
https://www.ncbi.nlm.nih.gov/pubmed/14157034
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author Salvin, S. B.
Smith, R. F.
author_facet Salvin, S. B.
Smith, R. F.
author_sort Salvin, S. B.
collection PubMed
description Adult guinea pigs were made unresponsive to a heterologous protein (e.g. bovine gamma globulin, or BGG) or a hapten-protein conjugate (e.g. p-aminobenzoic acid-bovine gamma globulin, or PABAγmiddot;BGG) by intraperitoneal injection of 80 mg cyclophosphamide and the specific antigen. This immunologic unresponsiveness developed to the specific antigen administered simultaneously with the cyclophosphamide, and not to any variants. Thus, animals unresponsive to PABAγmiddot;BGG remained unresponsive to the original antigen on challenge with a variant, but formed delayed hypersensitivity and circulating antibody to the variant. The specificity of immunologic unresponsiveness, therefore, seems more closely related to the whole antigen molecule than does delayed hypersensitivity.
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spelling pubmed-21377392008-04-17 THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS Salvin, S. B. Smith, R. F. J Exp Med Article Adult guinea pigs were made unresponsive to a heterologous protein (e.g. bovine gamma globulin, or BGG) or a hapten-protein conjugate (e.g. p-aminobenzoic acid-bovine gamma globulin, or PABAγmiddot;BGG) by intraperitoneal injection of 80 mg cyclophosphamide and the specific antigen. This immunologic unresponsiveness developed to the specific antigen administered simultaneously with the cyclophosphamide, and not to any variants. Thus, animals unresponsive to PABAγmiddot;BGG remained unresponsive to the original antigen on challenge with a variant, but formed delayed hypersensitivity and circulating antibody to the variant. The specificity of immunologic unresponsiveness, therefore, seems more closely related to the whole antigen molecule than does delayed hypersensitivity. The Rockefeller University Press 1964-05-01 /pmc/articles/PMC2137739/ /pubmed/14157034 Text en Copyright © 1964, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Salvin, S. B.
Smith, R. F.
THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title_full THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title_fullStr THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title_full_unstemmed THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title_short THE SPECIFICITY OF ALLERGIC REACTIONS : VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS
title_sort specificity of allergic reactions : vii. immunologic unresponsiveness, delayed hypersensitivity, and circulating antibody to proteins and hapten-protein conjugates in adult guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137739/
https://www.ncbi.nlm.nih.gov/pubmed/14157034
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