FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB

The fetal lamb was found to reject orthotopic skin homografts applied at any time after the 77th day of gestation. Prior to this, grafts remained in place without stimulating any detectable immunologic response. Once the fetus achieves the ability to reject the graft, the process occurs with the sam...

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Detalles Bibliográficos
Autores principales: Silverstein, Arthur M., Prendergast, Robert A., Kraner, Keith L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137752/
https://www.ncbi.nlm.nih.gov/pubmed/14176293
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author Silverstein, Arthur M.
Prendergast, Robert A.
Kraner, Keith L.
author_facet Silverstein, Arthur M.
Prendergast, Robert A.
Kraner, Keith L.
author_sort Silverstein, Arthur M.
collection PubMed
description The fetal lamb was found to reject orthotopic skin homografts applied at any time after the 77th day of gestation. Prior to this, grafts remained in place without stimulating any detectable immunologic response. Once the fetus achieves the ability to reject the graft, the process occurs with the same competence and rapidity as in the adult. Graft rejection in the fetal lamb is unaccompanied by formation of plasma cells or by the production of typical immunoglobulins, thus supporting the suggestion that circulating antibody does not play an obligatory role in the process.
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spelling pubmed-21377522008-04-17 FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB Silverstein, Arthur M. Prendergast, Robert A. Kraner, Keith L. J Exp Med Article The fetal lamb was found to reject orthotopic skin homografts applied at any time after the 77th day of gestation. Prior to this, grafts remained in place without stimulating any detectable immunologic response. Once the fetus achieves the ability to reject the graft, the process occurs with the same competence and rapidity as in the adult. Graft rejection in the fetal lamb is unaccompanied by formation of plasma cells or by the production of typical immunoglobulins, thus supporting the suggestion that circulating antibody does not play an obligatory role in the process. The Rockefeller University Press 1964-06-01 /pmc/articles/PMC2137752/ /pubmed/14176293 Text en Copyright © 1964, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Silverstein, Arthur M.
Prendergast, Robert A.
Kraner, Keith L.
FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title_full FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title_fullStr FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title_full_unstemmed FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title_short FETAL RESPONSE TO ANTIGENIC STIMULUS : IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB
title_sort fetal response to antigenic stimulus : iv. rejection of skin homografts by the fetal lamb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137752/
https://www.ncbi.nlm.nih.gov/pubmed/14176293
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