STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS

Intracellular levels of ATP, GTP, and hexose phosphates have been determined in HeLa cells at intervals after exposure to saturating doses of diphtheria toxin. Toxin causes no significant change in the level of any of these phosphorylated intermediates either in the presence or absence of glucose ov...

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Autores principales: Collier, R. J., Pappenheimer, A. M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137786/
https://www.ncbi.nlm.nih.gov/pubmed/14238921
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author Collier, R. J.
Pappenheimer, A. M.
author_facet Collier, R. J.
Pappenheimer, A. M.
author_sort Collier, R. J.
collection PubMed
description Intracellular levels of ATP, GTP, and hexose phosphates have been determined in HeLa cells at intervals after exposure to saturating doses of diphtheria toxin. Toxin causes no significant change in the level of any of these phosphorylated intermediates either in the presence or absence of glucose over a period of at least 5 to 6 hours. It is concluded that the inhibition of protein synthesis which occurs in HeLa cells at about 2 hours after the addition of saturating doses of toxin, does not result from an effect of toxin on energy metabolism.
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spelling pubmed-21377862008-04-17 STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS Collier, R. J. Pappenheimer, A. M. J Exp Med Article Intracellular levels of ATP, GTP, and hexose phosphates have been determined in HeLa cells at intervals after exposure to saturating doses of diphtheria toxin. Toxin causes no significant change in the level of any of these phosphorylated intermediates either in the presence or absence of glucose over a period of at least 5 to 6 hours. It is concluded that the inhibition of protein synthesis which occurs in HeLa cells at about 2 hours after the addition of saturating doses of toxin, does not result from an effect of toxin on energy metabolism. The Rockefeller University Press 1964-11-30 /pmc/articles/PMC2137786/ /pubmed/14238921 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Collier, R. J.
Pappenheimer, A. M.
STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title_full STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title_fullStr STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title_full_unstemmed STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title_short STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN : I. PHOSPHORYLATED INTERMEDIATES IN NORMAL AND INTOXICATED HELA CELLS
title_sort studies on the mode of action of diphtheria toxin : i. phosphorylated intermediates in normal and intoxicated hela cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137786/
https://www.ncbi.nlm.nih.gov/pubmed/14238921
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