SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY

Hybrid, bivalent antibody molecules bearing specific combining sites for both ovalbumin and bovine gamma globulin were produced by reoxidation of a mixture of the 3.5S fragments of the two specifically purified antibodies. The dual specificity and the properties of the hybrid antibody were demonstra...

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Detalles Bibliográficos
Autores principales: Fudenberg, H. H., Drews, Genevieve, Nisonoff, A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137801/
https://www.ncbi.nlm.nih.gov/pubmed/14113110
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author Fudenberg, H. H.
Drews, Genevieve
Nisonoff, A.
author_facet Fudenberg, H. H.
Drews, Genevieve
Nisonoff, A.
author_sort Fudenberg, H. H.
collection PubMed
description Hybrid, bivalent antibody molecules bearing specific combining sites for both ovalbumin and bovine gamma globulin were produced by reoxidation of a mixture of the 3.5S fragments of the two specifically purified antibodies. The dual specificity and the properties of the hybrid antibody were demonstrated by mixed agglutination and two stage agglutination experiments, and by test systems utilizing inhibition of agglutination or dispersal of agglutinates followed by antiglobulin reactions.
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spelling pubmed-21378012008-04-17 SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY Fudenberg, H. H. Drews, Genevieve Nisonoff, A. J Exp Med Article Hybrid, bivalent antibody molecules bearing specific combining sites for both ovalbumin and bovine gamma globulin were produced by reoxidation of a mixture of the 3.5S fragments of the two specifically purified antibodies. The dual specificity and the properties of the hybrid antibody were demonstrated by mixed agglutination and two stage agglutination experiments, and by test systems utilizing inhibition of agglutination or dispersal of agglutinates followed by antiglobulin reactions. The Rockefeller University Press 1964-01-01 /pmc/articles/PMC2137801/ /pubmed/14113110 Text en Copyright © 1964, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fudenberg, H. H.
Drews, Genevieve
Nisonoff, A.
SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title_full SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title_fullStr SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title_full_unstemmed SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title_short SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY
title_sort serologic demonstration of dual specificity of rabbit bivalent hybrid antibody
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137801/
https://www.ncbi.nlm.nih.gov/pubmed/14113110
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AT drewsgenevieve serologicdemonstrationofdualspecificityofrabbitbivalenthybridantibody
AT nisonoffa serologicdemonstrationofdualspecificityofrabbitbivalenthybridantibody

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