IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI

Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera to washed human or rabbit heart tissue homogenates exhibit precipitation with cell wall extract prepar...

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Detalles Bibliográficos
Autores principales: Kaplan, Melvin H., Suchy, Mary Louise
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137843/
https://www.ncbi.nlm.nih.gov/pubmed/14151104
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author Kaplan, Melvin H.
Suchy, Mary Louise
author_facet Kaplan, Melvin H.
Suchy, Mary Louise
author_sort Kaplan, Melvin H.
collection PubMed
description Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera to washed human or rabbit heart tissue homogenates exhibit precipitation with cell wall extract preparations. A single line of precipitation was observed in agar gel diffusion tests. Precipitating activity of goat antiheart sera was related to the γ-globulin fraction in zone electrophoresis. The cell wall antigen was demonstrated in cell wall extracts of a Type 5 and Type 19 but not of a Type 12 strain. Antigenic activity was concentrated in the same neutral salt and chromatographic fractions of acid extracts of cell wall previously reported to exhibit this activity by immunofluorescent inhibition of the cross-reaction of antistreptococcal serum with heart tissue.
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spelling pubmed-21378432008-04-17 IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI Kaplan, Melvin H. Suchy, Mary Louise J Exp Med Article Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera to washed human or rabbit heart tissue homogenates exhibit precipitation with cell wall extract preparations. A single line of precipitation was observed in agar gel diffusion tests. Precipitating activity of goat antiheart sera was related to the γ-globulin fraction in zone electrophoresis. The cell wall antigen was demonstrated in cell wall extracts of a Type 5 and Type 19 but not of a Type 12 strain. Antigenic activity was concentrated in the same neutral salt and chromatographic fractions of acid extracts of cell wall previously reported to exhibit this activity by immunofluorescent inhibition of the cross-reaction of antistreptococcal serum with heart tissue. The Rockefeller University Press 1964-03-31 /pmc/articles/PMC2137843/ /pubmed/14151104 Text en Copyright © 1964, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kaplan, Melvin H.
Suchy, Mary Louise
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title_full IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title_fullStr IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title_full_unstemmed IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title_short IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
title_sort immunologic relation of streptococcal and tissue antigens : ii. cross-reaction of antisera to mammalian heart tissue with a cell wall constituent of certain strains of group a streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137843/
https://www.ncbi.nlm.nih.gov/pubmed/14151104
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AT suchymarylouise immunologicrelationofstreptococcalandtissueantigensiicrossreactionofantiseratomammalianhearttissuewithacellwallconstituentofcertainstrainsofgroupastreptococci

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