THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS

The preparation, of an extract of hog blood vessels and organs containing renin activity has been described. The extract hydrolyzes natural or synthetic renin substrate to form a vasopressor material. This reaction could not be distinguished from the hydrolysis of renin substrates by kidney renin. T...

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Detalles Bibliográficos
Autores principales: Gould, Anne B., Skeggs, Leonard T., Kahn, Joseph R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137881/
https://www.ncbi.nlm.nih.gov/pubmed/14129710
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author Gould, Anne B.
Skeggs, Leonard T.
Kahn, Joseph R.
author_facet Gould, Anne B.
Skeggs, Leonard T.
Kahn, Joseph R.
author_sort Gould, Anne B.
collection PubMed
description The preparation, of an extract of hog blood vessels and organs containing renin activity has been described. The extract hydrolyzes natural or synthetic renin substrate to form a vasopressor material. This reaction could not be distinguished from the hydrolysis of renin substrates by kidney renin. The activation energy, effect of substrate concentration on velocity, inhibition by antirenin, and pH optimum of the extract and of kidney renin are the same. Renin activity is found in the adventitia and media of the aorta, the liver and, to a lesser extent, in other vascular organs.
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spelling pubmed-21378812008-04-17 THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS Gould, Anne B. Skeggs, Leonard T. Kahn, Joseph R. J Exp Med Article The preparation, of an extract of hog blood vessels and organs containing renin activity has been described. The extract hydrolyzes natural or synthetic renin substrate to form a vasopressor material. This reaction could not be distinguished from the hydrolysis of renin substrates by kidney renin. The activation energy, effect of substrate concentration on velocity, inhibition by antirenin, and pH optimum of the extract and of kidney renin are the same. Renin activity is found in the adventitia and media of the aorta, the liver and, to a lesser extent, in other vascular organs. The Rockefeller University Press 1964-02-29 /pmc/articles/PMC2137881/ /pubmed/14129710 Text en Copyright © 1964, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gould, Anne B.
Skeggs, Leonard T.
Kahn, Joseph R.
THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title_full THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title_fullStr THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title_full_unstemmed THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title_short THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
title_sort presence of renin activity in blood vessel walls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137881/
https://www.ncbi.nlm.nih.gov/pubmed/14129710
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