The fibrin-derived γ(377-395) peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to attenuate their activation remain elusive. Here, we identify fibrinogen as a novel regulator of microglia activation...

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Detalles Bibliográficos
Autores principales: Adams, Ryan A., Bauer, Jan, Flick, Matthew J., Sikorski, Shoana L., Nuriel, Tal, Lassmann, Hans, Degen, Jay L., Akassoglou, Katerina
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137908/
https://www.ncbi.nlm.nih.gov/pubmed/17339406
http://dx.doi.org/10.1084/jem.20061931

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