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Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice

Loss of interleukin (IL)-7 or the IL-7 receptor alpha (IL-7Rα, CD127) results in severe immunodeficiencies in mice and humans. To more precisely identify signals governing IL-7 function in vivo, we have disrupted the IL-7Rα Y449XXM motif in mice by knock-in mutagenesis (IL-7Rα(449F)). Thymic precurs...

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Detalles Bibliográficos
Autores principales:	Osborne, Lisa C., Dhanji, Salim, Snow, Jonathan W., Priatel, John J., Ma, Melissa C., Miners, M. Jill, Teh, Hung-Sia, Goldsmith, Mark A., Abraham, Ninan
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137912/ https://www.ncbi.nlm.nih.gov/pubmed/17325202 http://dx.doi.org/10.1084/jem.20061871

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