PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ

Activated Hageman factor, when injected into the rabbit ear chamber, produces a delayed and prolonged inflammatory response characterized by prominent sticking and emigration of leucocytes. In contrast, preformed bradykinin evokes an immediate and more transient response in which leucocytic emigrati...

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Detalles Bibliográficos
Autores principales: Graham, Richard C., Ebert, Robert H., Ratnoff, Oscar D., Moses, John M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138007/
https://www.ncbi.nlm.nih.gov/pubmed/14278232
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author Graham, Richard C.
Ebert, Robert H.
Ratnoff, Oscar D.
Moses, John M.
author_facet Graham, Richard C.
Ebert, Robert H.
Ratnoff, Oscar D.
Moses, John M.
author_sort Graham, Richard C.
collection PubMed
description Activated Hageman factor, when injected into the rabbit ear chamber, produces a delayed and prolonged inflammatory response characterized by prominent sticking and emigration of leucocytes. In contrast, preformed bradykinin evokes an immediate and more transient response in which leucocytic emigration occurs less frequently. It is concluded that either Hageman factor produces its inflammatory effects by mechanisms other than kinin release, or bradykinin released endogenously has effects quite different from those resulting from a single injection of the exogenous material.
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spelling pubmed-21380072008-04-17 PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ Graham, Richard C. Ebert, Robert H. Ratnoff, Oscar D. Moses, John M. J Exp Med Article Activated Hageman factor, when injected into the rabbit ear chamber, produces a delayed and prolonged inflammatory response characterized by prominent sticking and emigration of leucocytes. In contrast, preformed bradykinin evokes an immediate and more transient response in which leucocytic emigration occurs less frequently. It is concluded that either Hageman factor produces its inflammatory effects by mechanisms other than kinin release, or bradykinin released endogenously has effects quite different from those resulting from a single injection of the exogenous material. The Rockefeller University Press 1965-05-01 /pmc/articles/PMC2138007/ /pubmed/14278232 Text en Copyright © 1965 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Graham, Richard C.
Ebert, Robert H.
Ratnoff, Oscar D.
Moses, John M.
PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title_full PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title_fullStr PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title_full_unstemmed PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title_short PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ
title_sort pathogenesis of inflammation : ii. in vivo observations of the inflammatory effects of activated hageman factor and bradykinin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138007/
https://www.ncbi.nlm.nih.gov/pubmed/14278232
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AT ratnoffoscard pathogenesisofinflammationiiinvivoobservationsoftheinflammatoryeffectsofactivatedhagemanfactorandbradykinin
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