QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS

The cytocidal effect of specifically sensitized lymphoid cells on homologous target cells in culture can be inhibited by small quantities of an imidazole derivative of 6-mercaptopurine (imuran). This inhibition takes place only in the continuous presence of this drug, and at concentrations which app...

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Detalles Bibliográficos
Autor principal: Wilson, Darcy B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138029/
https://www.ncbi.nlm.nih.gov/pubmed/14330415
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author Wilson, Darcy B.
author_facet Wilson, Darcy B.
author_sort Wilson, Darcy B.
collection PubMed
description The cytocidal effect of specifically sensitized lymphoid cells on homologous target cells in culture can be inhibited by small quantities of an imidazole derivative of 6-mercaptopurine (imuran). This inhibition takes place only in the continuous presence of this drug, and at concentrations which apparently do not affect the viability of the attacking lymphoid cells. These results seem to support the contention that RNA-dependent protein synthesis on the part of the lymphoid cells is necessary for a destructive interaction between sensitized node cells and homologous target cells in vitro.
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spelling pubmed-21380292008-04-17 QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS Wilson, Darcy B. J Exp Med Article The cytocidal effect of specifically sensitized lymphoid cells on homologous target cells in culture can be inhibited by small quantities of an imidazole derivative of 6-mercaptopurine (imuran). This inhibition takes place only in the continuous presence of this drug, and at concentrations which apparently do not affect the viability of the attacking lymphoid cells. These results seem to support the contention that RNA-dependent protein synthesis on the part of the lymphoid cells is necessary for a destructive interaction between sensitized node cells and homologous target cells in vitro. The Rockefeller University Press 1965-07-01 /pmc/articles/PMC2138029/ /pubmed/14330415 Text en Copyright © 1965 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wilson, Darcy B.
QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title_full QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title_fullStr QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title_full_unstemmed QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title_short QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : II. INHIBITORY INFLUENCE OF THE IMMUNE SUPPRESSOR, IMURAN, ON THE DESTRUCTIVE REACTION OF SENSITIZED LYMPHOID CELLS AGAINST HOMOLOGOUS TARGET CELLS
title_sort quantitative studies on the behavior of sensitized lymphocytes in vitro : ii. inhibitory influence of the immune suppressor, imuran, on the destructive reaction of sensitized lymphoid cells against homologous target cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138029/
https://www.ncbi.nlm.nih.gov/pubmed/14330415
work_keys_str_mv AT wilsondarcyb quantitativestudiesonthebehaviorofsensitizedlymphocytesinvitroiiinhibitoryinfluenceoftheimmunesuppressorimuranonthedestructivereactionofsensitizedlymphoidcellsagainsthomologoustargetcells

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