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INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT

The bacterial flora of the gastrointestinal tract differs qualitatively and quantitatively from one colony of mice to another. Certain components of this flora, however, are always present in large and approximately constant numbers in healthy adult mice, irrespective of the colony from which the an...

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Detalles Bibliográficos
Autores principales: Dubos, René, Schaedler, Russell W., Costello, Richard, Hoet, Philippe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138034/
https://www.ncbi.nlm.nih.gov/pubmed/14325474
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author Dubos, René
Schaedler, Russell W.
Costello, Richard
Hoet, Philippe
author_facet Dubos, René
Schaedler, Russell W.
Costello, Richard
Hoet, Philippe
author_sort Dubos, René
collection PubMed
description The bacterial flora of the gastrointestinal tract differs qualitatively and quantitatively from one colony of mice to another. Certain components of this flora, however, are always present in large and approximately constant numbers in healthy adult mice, irrespective of the colony from which the animals are derived. Lactobacilli and anaerobic streptococci are extremely numerous in the stomach, the small intestine, and the large intestine. In contrast, organisms of the bacteroides group proliferate only in the large intestine. These three bacterial species persist at approximately constant levels in their characteristic localization throughout the life span of healthy animals. They are closely associated with the walls of the digestive organs, and are probably concentrated in the mucous layer. A few experiments carried out with rats and young swine indicate that lactobacilli are also present in large numbers in the stomach of these animal species. It is suggested that some of the components of the gastrointestinal flora have become symbiotic with their hosts in the course of evolutionary development and thus constitute a true autochthonous flora. The other components of the indigenous flora are acquired early in life either through accidental contact or because they are ubiquitous in the environment. The "normal" flora is that which is always present in the environment of the animal colony under consideration.
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spelling pubmed-21380342008-04-17 INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT Dubos, René Schaedler, Russell W. Costello, Richard Hoet, Philippe J Exp Med Article The bacterial flora of the gastrointestinal tract differs qualitatively and quantitatively from one colony of mice to another. Certain components of this flora, however, are always present in large and approximately constant numbers in healthy adult mice, irrespective of the colony from which the animals are derived. Lactobacilli and anaerobic streptococci are extremely numerous in the stomach, the small intestine, and the large intestine. In contrast, organisms of the bacteroides group proliferate only in the large intestine. These three bacterial species persist at approximately constant levels in their characteristic localization throughout the life span of healthy animals. They are closely associated with the walls of the digestive organs, and are probably concentrated in the mucous layer. A few experiments carried out with rats and young swine indicate that lactobacilli are also present in large numbers in the stomach of these animal species. It is suggested that some of the components of the gastrointestinal flora have become symbiotic with their hosts in the course of evolutionary development and thus constitute a true autochthonous flora. The other components of the indigenous flora are acquired early in life either through accidental contact or because they are ubiquitous in the environment. The "normal" flora is that which is always present in the environment of the animal colony under consideration. The Rockefeller University Press 1965-07-01 /pmc/articles/PMC2138034/ /pubmed/14325474 Text en Copyright © 1965 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dubos, René
Schaedler, Russell W.
Costello, Richard
Hoet, Philippe
INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title_full INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title_fullStr INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title_full_unstemmed INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title_short INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT
title_sort indigenous, normal, and autochthonous flora of the gastrointestinal tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138034/
https://www.ncbi.nlm.nih.gov/pubmed/14325474
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