EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY

In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when chal...

Descripción completa

Detalles Bibliográficos
Autores principales: Borel, Yves, Fauconnet, Marthe, Miescher, Peter A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138064/
https://www.ncbi.nlm.nih.gov/pubmed/14316945
_version_ 1782143475807944704
author Borel, Yves
Fauconnet, Marthe
Miescher, Peter A.
author_facet Borel, Yves
Fauconnet, Marthe
Miescher, Peter A.
author_sort Borel, Yves
collection PubMed
description In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.
format Text
id pubmed-2138064
institution National Center for Biotechnology Information
language English
publishDate 1965
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21380642008-04-17 EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY Borel, Yves Fauconnet, Marthe Miescher, Peter A. J Exp Med Article In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation. The Rockefeller University Press 1965-08-01 /pmc/articles/PMC2138064/ /pubmed/14316945 Text en Copyright © 1965 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Borel, Yves
Fauconnet, Marthe
Miescher, Peter A.
EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title_full EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title_fullStr EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title_full_unstemmed EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title_short EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY
title_sort effect of 6-mercaptopurine (6-mp) on different classes of antibody
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138064/
https://www.ncbi.nlm.nih.gov/pubmed/14316945
work_keys_str_mv AT borelyves effectof6mercaptopurine6mpondifferentclassesofantibody
AT fauconnetmarthe effectof6mercaptopurine6mpondifferentclassesofantibody
AT miescherpetera effectof6mercaptopurine6mpondifferentclassesofantibody

Ejemplares similares