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EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION

Two strains of selectively inbred rats were demonstrated previously to have opposite genetic predisposition to develop hypertension from NaCl ingestion (1, 2), DOCA-NaCl (3), and unilateral renal artery compression without NaCl (3). Using these same strains, similar disparate responses were elicited...

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Detalles Bibliográficos
Autores principales: Dahl, Lewis K., Heine, Martha, Tassinari, Lorraine
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138076/
https://www.ncbi.nlm.nih.gov/pubmed/5839285
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author Dahl, Lewis K.
Heine, Martha
Tassinari, Lorraine
author_facet Dahl, Lewis K.
Heine, Martha
Tassinari, Lorraine
author_sort Dahl, Lewis K.
collection PubMed
description Two strains of selectively inbred rats were demonstrated previously to have opposite genetic predisposition to develop hypertension from NaCl ingestion (1, 2), DOCA-NaCl (3), and unilateral renal artery compression without NaCl (3). Using these same strains, similar disparate responses were elicited with two other models for inducing experimental hypertension, namely cortisone and adrenal regeneration. On the basis of these experiences, it is proposed that the genetic substrate will be found to modify significantly the influence of all non-genetic factors considered to play a primary role in the etiology of experimental hypertension. Furthermore, it is suggested that similar genetic and non-genetic factors interact to produce hypertension in man. An hypothesis has been elaborated that is compatible with the experimental data and there is some clinical evidence to support this hypothesis.
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spelling pubmed-21380762008-04-17 EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION Dahl, Lewis K. Heine, Martha Tassinari, Lorraine J Exp Med Article Two strains of selectively inbred rats were demonstrated previously to have opposite genetic predisposition to develop hypertension from NaCl ingestion (1, 2), DOCA-NaCl (3), and unilateral renal artery compression without NaCl (3). Using these same strains, similar disparate responses were elicited with two other models for inducing experimental hypertension, namely cortisone and adrenal regeneration. On the basis of these experiences, it is proposed that the genetic substrate will be found to modify significantly the influence of all non-genetic factors considered to play a primary role in the etiology of experimental hypertension. Furthermore, it is suggested that similar genetic and non-genetic factors interact to produce hypertension in man. An hypothesis has been elaborated that is compatible with the experimental data and there is some clinical evidence to support this hypothesis. The Rockefeller University Press 1965-09-01 /pmc/articles/PMC2138076/ /pubmed/5839285 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dahl, Lewis K.
Heine, Martha
Tassinari, Lorraine
EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title_full EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title_fullStr EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title_full_unstemmed EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title_short EFFECTS OF CHRONIC EXCESS SALT INGESTION : FURTHER DEMONSTRATION THAT GENETIC FACTORS INFLUENCE THE DEVELOPMENT OF HYPERTENSION: EVIDENCE FROM EXPERIMENTAL HYPERTENSION DUE TO CORTISONE AND TO ADRENAL REGENERATION
title_sort effects of chronic excess salt ingestion : further demonstration that genetic factors influence the development of hypertension: evidence from experimental hypertension due to cortisone and to adrenal regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138076/
https://www.ncbi.nlm.nih.gov/pubmed/5839285
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