EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS

Rats with nephrotoxic serum nephritis were studied for the presence of a possible autoimmune response to renal antigens formed and/or liberated during the immunologic reactions taking place in the glomeruli. The experiments consisted of transplantation of a normal isologous kidney to a nephritic rat...

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Detalles Bibliográficos
Autores principales: Unanue, Emil R., Lee, Sun, Dixon, Frank J., Feldman, Joseph D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138077/
https://www.ncbi.nlm.nih.gov/pubmed/5320431
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author Unanue, Emil R.
Lee, Sun
Dixon, Frank J.
Feldman, Joseph D.
author_facet Unanue, Emil R.
Lee, Sun
Dixon, Frank J.
Feldman, Joseph D.
author_sort Unanue, Emil R.
collection PubMed
description Rats with nephrotoxic serum nephritis were studied for the presence of a possible autoimmune response to renal antigens formed and/or liberated during the immunologic reactions taking place in the glomeruli. The experiments consisted of transplantation of a normal isologous kidney to a nephritic rat and parabiosis of a normal rat to a nephritic rat. Neither functional nor morphologic abnormalities were noted in the normal kidneys in either situation. Transfer of the rabbit nephrotoxic antibody to the normal kidneys was noted in both experiments, indicating a continual dissociation and reassociation of nephrotoxic antibody with the tissue antigens of the host. Some of the nephritic rats showed a decrease in proteinuria and a slowing in the progression of the nephritis during the period in which the normal kidney was transplanted or a normal rat was united in parabiosis.
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spelling pubmed-21380772008-04-17 EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS Unanue, Emil R. Lee, Sun Dixon, Frank J. Feldman, Joseph D. J Exp Med Article Rats with nephrotoxic serum nephritis were studied for the presence of a possible autoimmune response to renal antigens formed and/or liberated during the immunologic reactions taking place in the glomeruli. The experiments consisted of transplantation of a normal isologous kidney to a nephritic rat and parabiosis of a normal rat to a nephritic rat. Neither functional nor morphologic abnormalities were noted in the normal kidneys in either situation. Transfer of the rabbit nephrotoxic antibody to the normal kidneys was noted in both experiments, indicating a continual dissociation and reassociation of nephrotoxic antibody with the tissue antigens of the host. Some of the nephritic rats showed a decrease in proteinuria and a slowing in the progression of the nephritis during the period in which the normal kidney was transplanted or a normal rat was united in parabiosis. The Rockefeller University Press 1965-09-01 /pmc/articles/PMC2138077/ /pubmed/5320431 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Unanue, Emil R.
Lee, Sun
Dixon, Frank J.
Feldman, Joseph D.
EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title_full EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title_fullStr EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title_full_unstemmed EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title_short EXPERIMENTAL GLOMERULONEPHRITIS : VII. THE ABSENCE OF AN AUTOIMMUNE ANTIKIDNEY RESPONSE IN NEPHROTOXIC SERUM NEPHRITIS
title_sort experimental glomerulonephritis : vii. the absence of an autoimmune antikidney response in nephrotoxic serum nephritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138077/
https://www.ncbi.nlm.nih.gov/pubmed/5320431
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