THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI

Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from...

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Detalles Bibliográficos
Autores principales: Chase, Randolph M., Rapaport, Felix T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138081/
https://www.ncbi.nlm.nih.gov/pubmed/5321602
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author Chase, Randolph M.
Rapaport, Felix T.
author_facet Chase, Randolph M.
Rapaport, Felix T.
author_sort Chase, Randolph M.
collection PubMed
description Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. The gross and histologic appearance of these grafts is identical with that observed in similar reactions obtained in guinea pigs sensitized with homologous tissues. The ability of Group A hemolytic streptococci to induce homograft sensitivity in the guinea pig is a property shared by Types 4, 5, 6, 11, 12, 14, and 49 of Group A streptococci.
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spelling pubmed-21380812008-04-17 THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI Chase, Randolph M. Rapaport, Felix T. J Exp Med Article Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. The gross and histologic appearance of these grafts is identical with that observed in similar reactions obtained in guinea pigs sensitized with homologous tissues. The ability of Group A hemolytic streptococci to induce homograft sensitivity in the guinea pig is a property shared by Types 4, 5, 6, 11, 12, 14, and 49 of Group A streptococci. The Rockefeller University Press 1965-10-01 /pmc/articles/PMC2138081/ /pubmed/5321602 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Chase, Randolph M.
Rapaport, Felix T.
THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title_full THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title_fullStr THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title_full_unstemmed THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title_short THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
title_sort bacterial induction of homograft sensitivity : i. effects of sensitization with group a streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138081/
https://www.ncbi.nlm.nih.gov/pubmed/5321602
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