ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE

The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G(60)L(40), G(60)A(40), G(90)T(10)). Upon introduction of as little as 4 mole per cent...

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Detalles Bibliográficos
Autores principales: Pinchuck, Paul, Maurer, Paul H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138089/
https://www.ncbi.nlm.nih.gov/pubmed/5849232
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author Pinchuck, Paul
Maurer, Paul H.
author_facet Pinchuck, Paul
Maurer, Paul H.
author_sort Pinchuck, Paul
collection PubMed
description The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G(60)L(40), G(60)A(40), G(90)T(10)). Upon introduction of as little as 4 mole per cent of a third amino acid, good immune responses were obtained, regardless of the nature of the third amino acid. The level of the immune response to a series of glu-lys-ala polymers increased with increasing alanine content of the polymer.
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spelling pubmed-21380892008-04-17 ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE Pinchuck, Paul Maurer, Paul H. J Exp Med Article The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G(60)L(40), G(60)A(40), G(90)T(10)). Upon introduction of as little as 4 mole per cent of a third amino acid, good immune responses were obtained, regardless of the nature of the third amino acid. The level of the immune response to a series of glu-lys-ala polymers increased with increasing alanine content of the polymer. The Rockefeller University Press 1965-10-01 /pmc/articles/PMC2138089/ /pubmed/5849232 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Pinchuck, Paul
Maurer, Paul H.
ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title_full ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title_fullStr ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title_full_unstemmed ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title_short ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
title_sort antigenicity of polypeptides (poly alpha amino acids) : xv. studies on the immunogenicity of synthetic polypeptides in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138089/
https://www.ncbi.nlm.nih.gov/pubmed/5849232
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AT maurerpaulh antigenicityofpolypeptidespolyalphaaminoacidsxvstudiesontheimmunogenicityofsyntheticpolypeptidesinmice

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