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THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS

Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recip...

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Detalles Bibliográficos
Autores principales: Rapaport, Felix T., Chase, Randolph M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138093/
https://www.ncbi.nlm.nih.gov/pubmed/4379017
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author Rapaport, Felix T.
Chase, Randolph M.
author_facet Rapaport, Felix T.
Chase, Randolph M.
author_sort Rapaport, Felix T.
collection PubMed
description Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. Other bacteria tested included Lancefield streptococcal groups B, C, D, E, G, H, L, and O, pneumococcus Types II, III, XIV and a rough strain, Corynebacterium xerosis, Bacillus subtilis, Escherichia coli, Aerobacter aerogenes, Salmonella typhimurium, Proteus vulgaris, Neisseria catarrhalis, Haemophilus influenzae, and two human virulent strains of Mycobacterium tuberculosis. None of these microorganisms was active in the induction of homograft sensitivity in the guinea pig. Pretreatment of recipients with Gram-negative bacterial suspensions was associated with a slight increase in the mean survival time of first-set skin homografts. Results of this study suggest the presence in staphylococci, as well as in Group A streptococci, of antigens related in their biologic effects to tissue transplantation antigens.
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spelling pubmed-21380932008-04-17 THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS Rapaport, Felix T. Chase, Randolph M. J Exp Med Article Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. Other bacteria tested included Lancefield streptococcal groups B, C, D, E, G, H, L, and O, pneumococcus Types II, III, XIV and a rough strain, Corynebacterium xerosis, Bacillus subtilis, Escherichia coli, Aerobacter aerogenes, Salmonella typhimurium, Proteus vulgaris, Neisseria catarrhalis, Haemophilus influenzae, and two human virulent strains of Mycobacterium tuberculosis. None of these microorganisms was active in the induction of homograft sensitivity in the guinea pig. Pretreatment of recipients with Gram-negative bacterial suspensions was associated with a slight increase in the mean survival time of first-set skin homografts. Results of this study suggest the presence in staphylococci, as well as in Group A streptococci, of antigens related in their biologic effects to tissue transplantation antigens. The Rockefeller University Press 1965-10-01 /pmc/articles/PMC2138093/ /pubmed/4379017 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rapaport, Felix T.
Chase, Randolph M.
THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title_full THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title_fullStr THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title_full_unstemmed THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title_short THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS
title_sort bacterial induction of homograft sensitivity : ii. effects of sensitization with staphylococci and other microorganisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138093/
https://www.ncbi.nlm.nih.gov/pubmed/4379017
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