STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS

Lymphocytes from the peripheral blood of newborn rabbits heterozygous for IgG allotypes As4 and As5, or As5 and As6, obtained at an age when only the maternal allotypic determinants are detectable in the serum, may be stimulated in vitro to transform into "blast" cells with antiallotype se...

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Detalles Bibliográficos
Autores principales: Sell, Stewart, Gell, P. G. H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138116/
https://www.ncbi.nlm.nih.gov/pubmed/4159058
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author Sell, Stewart
Gell, P. G. H.
author_facet Sell, Stewart
Gell, P. G. H.
author_sort Sell, Stewart
collection PubMed
description Lymphocytes from the peripheral blood of newborn rabbits heterozygous for IgG allotypes As4 and As5, or As5 and As6, obtained at an age when only the maternal allotypic determinants are detectable in the serum, may be stimulated in vitro to transform into "blast" cells with antiallotype sera directed against the determinants contolled both by the maternal and by the paternal chromosomes. This result rules out the possibility that allotypic specificity is conferred upon lymphocytes by environmental IgG and suggests that the lymphocytes of newborn rabbits have the potential to synthesize IgG determinants either in the form of intact IgG molecules or constituent polypeptide chains.
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spelling pubmed-21381162008-04-17 STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS Sell, Stewart Gell, P. G. H. J Exp Med Article Lymphocytes from the peripheral blood of newborn rabbits heterozygous for IgG allotypes As4 and As5, or As5 and As6, obtained at an age when only the maternal allotypic determinants are detectable in the serum, may be stimulated in vitro to transform into "blast" cells with antiallotype sera directed against the determinants contolled both by the maternal and by the paternal chromosomes. This result rules out the possibility that allotypic specificity is conferred upon lymphocytes by environmental IgG and suggests that the lymphocytes of newborn rabbits have the potential to synthesize IgG determinants either in the form of intact IgG molecules or constituent polypeptide chains. The Rockefeller University Press 1965-10-31 /pmc/articles/PMC2138116/ /pubmed/4159058 Text en Copyright © 1965 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sell, Stewart
Gell, P. G. H.
STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title_full STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title_fullStr STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title_full_unstemmed STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title_short STUDIES ON RABBIT LYMPHOCYTES IN VITRO : IV. BLAST TRANSFORMATION OF THE LYMPHOCYTES FROM NEWBORN RABBITS INDUCED BY ANTIALLOTYPE SERUM TO A PATERNAL IGG ALLOTYPE NOT PRESENT IN THE SERUM OF THE LYMPHOCYTE DONORS
title_sort studies on rabbit lymphocytes in vitro : iv. blast transformation of the lymphocytes from newborn rabbits induced by antiallotype serum to a paternal igg allotype not present in the serum of the lymphocyte donors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138116/
https://www.ncbi.nlm.nih.gov/pubmed/4159058
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AT gellpgh studiesonrabbitlymphocytesinvitroivblasttransformationofthelymphocytesfromnewbornrabbitsinducedbyantiallotypeserumtoapaternaliggallotypenotpresentintheserumofthelymphocytedonors

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