CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE

Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarty, Daniel J., Phelps, Paulding, Pyenson, Jacob
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138217/
https://www.ncbi.nlm.nih.gov/pubmed/4287616
_version_ 1782143511877910528
author McCarty, Daniel J.
Phelps, Paulding
Pyenson, Jacob
author_facet McCarty, Daniel J.
Phelps, Paulding
Pyenson, Jacob
author_sort McCarty, Daniel J.
collection PubMed
description Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man.
format Text
id pubmed-2138217
institution National Center for Biotechnology Information
language English
publishDate 1966
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21382172008-04-17 CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE McCarty, Daniel J. Phelps, Paulding Pyenson, Jacob J Exp Med Article Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man. The Rockefeller University Press 1966-07-01 /pmc/articles/PMC2138217/ /pubmed/4287616 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McCarty, Daniel J.
Phelps, Paulding
Pyenson, Jacob
CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title_full CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title_fullStr CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title_full_unstemmed CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title_short CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : I. AN EXPERIMENTAL MODEL WITH QUANTIFICATION OF THE HOST RESPONSE
title_sort crystal-induced inflammation in canine joints : i. an experimental model with quantification of the host response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138217/
https://www.ncbi.nlm.nih.gov/pubmed/4287616
work_keys_str_mv AT mccartydanielj crystalinducedinflammationincaninejointsianexperimentalmodelwithquantificationofthehostresponse
AT phelpspaulding crystalinducedinflammationincaninejointsianexperimentalmodelwithquantificationofthehostresponse
AT pyensonjacob crystalinducedinflammationincaninejointsianexperimentalmodelwithquantificationofthehostresponse

Ejemplares similares