CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES

In an experimental model, the polymorphonuclear leukocyte was found to be necessary to the inflammation induced by crystals. This conclusion is based on (a) the invariable migration of polymorphonuclear leukocytes into the synovial fluid of canine joints injected with urate crystals, (b) the experim...

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Detalles Bibliográficos
Autores principales: Phelps, Paulding, McCarty, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138225/
https://www.ncbi.nlm.nih.gov/pubmed/5944345
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author Phelps, Paulding
McCarty, Daniel J.
author_facet Phelps, Paulding
McCarty, Daniel J.
author_sort Phelps, Paulding
collection PubMed
description In an experimental model, the polymorphonuclear leukocyte was found to be necessary to the inflammation induced by crystals. This conclusion is based on (a) the invariable migration of polymorphonuclear leukocytes into the synovial fluid of canine joints injected with urate crystals, (b) the experimental suppression of the synovitis by the depletion of polymorphonuclear leukocytes in animals treated with vinblastine, (c) the dependence of the degree of suppression on the degree of leukocyte mobilization into the joint space, and (d) the restoration of the inflammatory response in a leukopenic animal by perfusion with normal blood.
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spelling pubmed-21382252008-04-17 CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES Phelps, Paulding McCarty, Daniel J. J Exp Med Article In an experimental model, the polymorphonuclear leukocyte was found to be necessary to the inflammation induced by crystals. This conclusion is based on (a) the invariable migration of polymorphonuclear leukocytes into the synovial fluid of canine joints injected with urate crystals, (b) the experimental suppression of the synovitis by the depletion of polymorphonuclear leukocytes in animals treated with vinblastine, (c) the dependence of the degree of suppression on the degree of leukocyte mobilization into the joint space, and (d) the restoration of the inflammatory response in a leukopenic animal by perfusion with normal blood. The Rockefeller University Press 1966-07-01 /pmc/articles/PMC2138225/ /pubmed/5944345 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Phelps, Paulding
McCarty, Daniel J.
CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title_full CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title_fullStr CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title_full_unstemmed CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title_short CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS : II. IMPORTANCE OF POLYMORPHONUCLEAR LEUKOCYTES
title_sort crystal-induced inflammation in canine joints : ii. importance of polymorphonuclear leukocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138225/
https://www.ncbi.nlm.nih.gov/pubmed/5944345
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AT mccartydanielj crystalinducedinflammationincaninejointsiiimportanceofpolymorphonuclearleukocytes

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