STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION

Leukocyte migration was studied in a microhematocrit system which permitted evaluation of the separate effects of leukocyte adhesiveness, intrinsic cell motility, and leukocyte clumping. Leukocyte adhesion to glass required the presence of magnesium ion, was totally independent of calcium ion, and w...

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Autores principales: Bryant, Richard E., DesPrez, Roger M., VanWay, Margery H., Rogers, David E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138230/
https://www.ncbi.nlm.nih.gov/pubmed/4958802
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author Bryant, Richard E.
DesPrez, Roger M.
VanWay, Margery H.
Rogers, David E.
author_facet Bryant, Richard E.
DesPrez, Roger M.
VanWay, Margery H.
Rogers, David E.
author_sort Bryant, Richard E.
collection PubMed
description Leukocyte migration was studied in a microhematocrit system which permitted evaluation of the separate effects of leukocyte adhesiveness, intrinsic cell motility, and leukocyte clumping. Leukocyte adhesion to glass required the presence of magnesium ion, was totally independent of calcium ion, and was partially dependent on heat-labile plasma factors. Leukocyte migration was unimpaired by marked acidosis or by wide variations in sodium, potassium, or calcium concentrations. Marked impairment of individual leukocyte motility and increased leukocyte aggregation were observed after phagocytosis of particulate matter, suggesting a mechanism facilitating recruitment and retention of leukocytes at areas of microbial invasion.
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spelling pubmed-21382302008-04-17 STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION Bryant, Richard E. DesPrez, Roger M. VanWay, Margery H. Rogers, David E. J Exp Med Article Leukocyte migration was studied in a microhematocrit system which permitted evaluation of the separate effects of leukocyte adhesiveness, intrinsic cell motility, and leukocyte clumping. Leukocyte adhesion to glass required the presence of magnesium ion, was totally independent of calcium ion, and was partially dependent on heat-labile plasma factors. Leukocyte migration was unimpaired by marked acidosis or by wide variations in sodium, potassium, or calcium concentrations. Marked impairment of individual leukocyte motility and increased leukocyte aggregation were observed after phagocytosis of particulate matter, suggesting a mechanism facilitating recruitment and retention of leukocytes at areas of microbial invasion. The Rockefeller University Press 1966-09-01 /pmc/articles/PMC2138230/ /pubmed/4958802 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bryant, Richard E.
DesPrez, Roger M.
VanWay, Margery H.
Rogers, David E.
STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title_full STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title_fullStr STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title_full_unstemmed STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title_short STUDIES ON HUMAN LEUKOCYTE MOTILITY : I. EFFECTS OF ALTERATIONS IN PH, ELECTROLYTE CONCENTRATION, AND PHAGOCYTOSIS ON LEUKOCYTE MIGRATION, ADHESIVENESS, AND AGGREGATION
title_sort studies on human leukocyte motility : i. effects of alterations in ph, electrolyte concentration, and phagocytosis on leukocyte migration, adhesiveness, and aggregation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138230/
https://www.ncbi.nlm.nih.gov/pubmed/4958802
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