THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS

The ultrastructure of three mycoplasma species, Mycoplasma pneumoniae, Mycoplasma gallisepticum, and Mycoplasma neurolyticum, has been studied in isolated form as well as in HeLa cell cultures and following incubation with human peripheral blood leukocytes. During log growth phase, the organisms cou...

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Autores principales: Zucker-Franklin, Dorothea, Davidson, Morton, Thomas, Lewis
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138233/
https://www.ncbi.nlm.nih.gov/pubmed/5922745
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author Zucker-Franklin, Dorothea
Davidson, Morton
Thomas, Lewis
author_facet Zucker-Franklin, Dorothea
Davidson, Morton
Thomas, Lewis
author_sort Zucker-Franklin, Dorothea
collection PubMed
description The ultrastructure of three mycoplasma species, Mycoplasma pneumoniae, Mycoplasma gallisepticum, and Mycoplasma neurolyticum, has been studied in isolated form as well as in HeLa cell cultures and following incubation with human peripheral blood leukocytes. During log growth phase, the organisms could be distinguished from each other on the basis of their fine structure. In mammalian cell cultures, PPLO's appeared to proliferate on the plasma membranes which had markedly increased their surface area by means of long cytoplasmic processes which extended toward and surrounded them. Some of the microorganisms affected in this way may well have lain, not in vacuoles, but at the bottom of crypts. It is suggested that the cytopathogenic effect exerted by PPLO's on some tissue cultures may be attributable to membrane damage. Mycoplasmas adhered to leukocyte plasma membranes in a similar manner. They were avidly phagocytosed by neutrophils and eosinophils with accompanying degranulation of the white cells. It is thus likely that the local inflammatory reaction induced by PPLO's does not differ in essence from that caused by bacteria.
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spelling pubmed-21382332008-04-17 THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS Zucker-Franklin, Dorothea Davidson, Morton Thomas, Lewis J Exp Med Article The ultrastructure of three mycoplasma species, Mycoplasma pneumoniae, Mycoplasma gallisepticum, and Mycoplasma neurolyticum, has been studied in isolated form as well as in HeLa cell cultures and following incubation with human peripheral blood leukocytes. During log growth phase, the organisms could be distinguished from each other on the basis of their fine structure. In mammalian cell cultures, PPLO's appeared to proliferate on the plasma membranes which had markedly increased their surface area by means of long cytoplasmic processes which extended toward and surrounded them. Some of the microorganisms affected in this way may well have lain, not in vacuoles, but at the bottom of crypts. It is suggested that the cytopathogenic effect exerted by PPLO's on some tissue cultures may be attributable to membrane damage. Mycoplasmas adhered to leukocyte plasma membranes in a similar manner. They were avidly phagocytosed by neutrophils and eosinophils with accompanying degranulation of the white cells. It is thus likely that the local inflammatory reaction induced by PPLO's does not differ in essence from that caused by bacteria. The Rockefeller University Press 1966-09-01 /pmc/articles/PMC2138233/ /pubmed/5922745 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Zucker-Franklin, Dorothea
Davidson, Morton
Thomas, Lewis
THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title_full THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title_fullStr THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title_full_unstemmed THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title_short THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
title_sort interaction of mycoplasmas with mammalian cells : i. hela cells, neutrophils, and eosinophils
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138233/
https://www.ncbi.nlm.nih.gov/pubmed/5922745
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