TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM

Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized l...

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Detalles Bibliográficos
Autores principales: Lerner, Richard A., Dixon, Frank J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138241/
https://www.ncbi.nlm.nih.gov/pubmed/5922743
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author Lerner, Richard A.
Dixon, Frank J.
author_facet Lerner, Richard A.
Dixon, Frank J.
author_sort Lerner, Richard A.
collection PubMed
description Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of γG- and β1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes.
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spelling pubmed-21382412008-04-17 TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM Lerner, Richard A. Dixon, Frank J. J Exp Med Article Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of γG- and β1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes. The Rockefeller University Press 1966-09-01 /pmc/articles/PMC2138241/ /pubmed/5922743 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lerner, Richard A.
Dixon, Frank J.
TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title_full TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title_fullStr TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title_full_unstemmed TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title_short TRANSFER OF OVINE EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS (EAG) WITH SERUM
title_sort transfer of ovine experimental allergic glomerulonephritis (eag) with serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138241/
https://www.ncbi.nlm.nih.gov/pubmed/5922743
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