DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-de...

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Detalles Bibliográficos
Autores principales: Rother, Klaus, Rother, Ursula, Müller-Eberhard, Hans J., Nilsson, Ulf R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138255/
https://www.ncbi.nlm.nih.gov/pubmed/5922290
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author Rother, Klaus
Rother, Ursula
Müller-Eberhard, Hans J.
Nilsson, Ulf R.
author_facet Rother, Klaus
Rother, Ursula
Müller-Eberhard, Hans J.
Nilsson, Ulf R.
author_sort Rother, Klaus
collection PubMed
description A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.
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spelling pubmed-21382552008-04-17 DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT Rother, Klaus Rother, Ursula Müller-Eberhard, Hans J. Nilsson, Ulf R. J Exp Med Article A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form. The Rockefeller University Press 1966-10-01 /pmc/articles/PMC2138255/ /pubmed/5922290 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rother, Klaus
Rother, Ursula
Müller-Eberhard, Hans J.
Nilsson, Ulf R.
DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title_full DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title_fullStr DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title_full_unstemmed DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title_short DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT
title_sort deficiency of the sixth component of complement in rabbits with an inherited complement defect
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138255/
https://www.ncbi.nlm.nih.gov/pubmed/5922290
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AT mullereberhardhansj deficiencyofthesixthcomponentofcomplementinrabbitswithaninheritedcomplementdefect
AT nilssonulfr deficiencyofthesixthcomponentofcomplementinrabbitswithaninheritedcomplementdefect

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